Results 71 to 80 of about 4,076,651 (345)

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

open access: yesFEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican   +7 more
wiley   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

open access: yesFEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona   +4 more
wiley   +1 more source

On topologies over rings

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 1985
In this note, we show that if a topology F¯ over a ring A satisfies a certain finiteness condition, then the Gabriel topology G¯ generated by F¯ can be explicitly constructed and it also satisfies the same finiteness condition.
Syed M. Fakhruddin
doaj   +1 more source

Using the Kalman Algorithm to Correct Data Errors of a 24-Bit Visible Spectrometer

open access: yesSensors, 2017
To reduce cost, increase resolution, and reduce errors due to changing light intensity of the VIS SPEC, a new technique is proposed which applies the Kalman algorithm along with a simple hardware setup and implementation.
Son Pham, Anh Dinh
doaj   +1 more source

CPHD filter derivation for extended targets [PDF]

open access: yes, 2010
This document derives the CPHD filter for extended targets. Only the update step is derived here. Target generated measurements, false alarms and prior are all assumed to be independent identically distributed cluster processes.
Orguner, Umut
core  

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

open access: yesFEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura   +8 more
wiley   +1 more source

Coupling coefficients of different disk microresonators with whispering gallery modes

open access: yesVìsnik Nacìonalʹnogo Tehnìčnogo Unìversitetu Ukraïni Kììvsʹkij Polìtehnìčnij Ìnstitut: Serìâ Radìotehnìka, Radìoaparatobuduvannâ, 2017
The coupling coefficients of the disk microresonators consisting of different dielectrics are presented. The analytical expressions for the coupling coefficients are obtained.
A. A. Trubin
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Effect of Sectional Polymerization Process on Tunable Twist Structure Liquid Crystal Filters

open access: yesCrystals, 2019
The effect of sectional polymerization process on tunable filters with cholesteric liquid crystal (CLC) and blue phase liquid crystal (BPLC) is demonstrated.
Changli Sun, Jiangang Lu
doaj   +1 more source

Fast Incremental Spectral Clustering in Titanate Application via Graph Fourier Transform

open access: yesIEEE Access, 2020
In numerous applications the rapid increase of data size with time makes classical clustering algorithms too slow because of the high computational cost.
Gao Shu-Juan
doaj   +1 more source

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