Results 71 to 80 of about 4,076,651 (345)
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona +4 more
wiley +1 more source
In this note, we show that if a topology F¯ over a ring A satisfies a certain finiteness condition, then the Gabriel topology G¯ generated by F¯ can be explicitly constructed and it also satisfies the same finiteness condition.
Syed M. Fakhruddin
doaj +1 more source
Using the Kalman Algorithm to Correct Data Errors of a 24-Bit Visible Spectrometer
To reduce cost, increase resolution, and reduce errors due to changing light intensity of the VIS SPEC, a new technique is proposed which applies the Kalman algorithm along with a simple hardware setup and implementation.
Son Pham, Anh Dinh
doaj +1 more source
CPHD filter derivation for extended targets [PDF]
This document derives the CPHD filter for extended targets. Only the update step is derived here. Target generated measurements, false alarms and prior are all assumed to be independent identically distributed cluster processes.
Orguner, Umut
core
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
Coupling coefficients of different disk microresonators with whispering gallery modes
The coupling coefficients of the disk microresonators consisting of different dielectrics are presented. The analytical expressions for the coupling coefficients are obtained.
A. A. Trubin
doaj +1 more source
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Effect of Sectional Polymerization Process on Tunable Twist Structure Liquid Crystal Filters
The effect of sectional polymerization process on tunable filters with cholesteric liquid crystal (CLC) and blue phase liquid crystal (BPLC) is demonstrated.
Changli Sun, Jiangang Lu
doaj +1 more source
Fast Incremental Spectral Clustering in Titanate Application via Graph Fourier Transform
In numerous applications the rapid increase of data size with time makes classical clustering algorithms too slow because of the high computational cost.
Gao Shu-Juan
doaj +1 more source

