Results 61 to 70 of about 297,748 (266)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

On the Global Convergence of a Filter--SQP Algorithm

open access: yesSIAM Journal on Optimization, 2002
A mechanism for proving global convergence in sequential quadratic programming (SQP) filter methods for nonlinear programs is described. The proposed algorithm contains a convergent inner iteration for calculating a suitable trust region radius.
Roger Fletcher   +2 more
openaire   +3 more sources

Recursive Least-Squares Lattice Algorithm Combined With Secondary-Path Innovation and Lattice-Order Decision Algorithms for Active Noise Control

open access: yesIEEE Access, 2020
This paper proposes a new active noise control (ANC) system based on a recursive least-squares lattice (RLSL) algorithm by designing secondary-path innovation (SPI) and lattice-order decision (LOD) algorithms.
Dong Woo Kim, Poogyeon Park
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Two-Stage Kalman Filter for Fault Tolerant Estimation of Wind Speed and UAV Flight Parameters

open access: yesMeasurement Science Review, 2020
In this study, an estimation algorithm based on a two-stage Kalman filter (TSKF) was developed for wind speed and Unmanned Aerial Vehicle (UAV) motion parameters. In the first stage, the wind speed estimation algorithm is used with the help of the Global
Hajiyev Chingiz   +2 more
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

A New Adaptive H-Infinity Filtering Algorithm for the GPS/INS Integrated Navigation

open access: yesSensors, 2016
The Kalman filter is an optimal estimator with numerous applications in technology, especially in systems with Gaussian distributed noise. Moreover, the adaptive Kalman filtering algorithms, based on the Kalman filter, can control the influence of ...
Chen Jiang, Shu-Bi Zhang, Qiu-Zhao Zhang
doaj   +1 more source

Perbandingan Algoritma Contraharmonic Mean Filter dan Arithmetic Mean Filter untuk Mereduksi Exponential Noise

open access: yesJISKA (Jurnal Informatika Sunan Kalijaga), 2020
Noise in the image caused a decrease in image quality, so that the image will look dirty and spots appear on the resulting image. Noise also results in reduced information on the resulting image so that noise limits valuable information when image ...
Mhd Furqan   +2 more
doaj   +1 more source

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