Results 91 to 100 of about 491,522 (274)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Methods of temporal signal processing in an adaptive transversal filter

Journal of Radio Electronics
A single-channel adaptive transversal filter based on a multi-tap delay line is considered. It is assumed that the filter is affected by broadband interference, which is a rather complicated case in practice. This problem is typical for radar systems and electronic warfare systems. Two methods of digital signal processing are proposed. The first method
openaire   +1 more source

Bayesian Methods for Multi-Objective Optimization of Hybrid Numerical Filters in ECG Signal Processing for Accurate Arrhythmia Classification

Statistics, Optimization & Information Computing
This study introduces an innovative method for ECG signal processing that combines advanced filtering techniques, multi-objective Bayesian optimization, and a sophisticated deep learning architecture for classification. The methodology starts with Enhanced Empirical Mode Decomposition (EEMD) to break down the ECG signal into Intrinsic Mode Functions ...
Zakaria Khatar, Dounia Bentaleb, Saadia Drissi   +2 more
openaire   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Development of FPGA-Based Data Acquisition System for Metallic Magnetic Calorimeter

Journal of Isotopes
Metallic magnetic calorimeters are a class of low-temperature particle detectors based on calorimetry，utilizing metallic paramagnetic temperature sensors to convert the temperature rise of an absorber upon the absorption of incident particle energy into ...
Yang LI, Lijun XU, Yuntao LIU, Baoji ZHU, Yuhe ZHANG, Qi JIN, Zongzheng ZHOU, Yuanqiao LI, Min LIN, Lijie HAO, Hongliang WANG, Shichun JIN   +11 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Anti-interference methods for narrowband and repeater-modulation interference in airborne SAR systems

Journal of Electronic Science and Technology
With the advancement of electronic countermeasures, airborne synthetic aperture radar (SAR) systems are facing increasing challenges in maintaining effective performance in hostile environments. In particular, high-power interference can severely degrade
Kai Chen, Yong-Bo Zhao, Kai Jiang, Long Sun, Kun Deng, Chang-Chun Ding   +5 more
doaj   +1 more source

Processing Technology Based on Radar Signal Design and Classification

International Journal of Aerospace Engineering, 2020
It is well known that the application of radar is becoming more and more popular with the development of the signal technology progress. This paper lists the current radar signal research, the technical progress achieved, and the existing limitations ...
Jianping Ou, Jun Zhang, Ronghui Zhan
doaj   +1 more source

Electronic filters, repeated signal charge conversion apparatus, hearing aids and methods [PDF]

, 1993
An electronic filter for filtering an electrical signal. Signal processing circuitry therein includes a logarithmic filter having a series of filter stages with inputs and outputs in cascade and respective circuits associated with the filter stages for ...
Engebretson, A. Maynard, Engel, George L., Morley, Jr., Robert E., Sullivan, Thomas J.   +3 more
core   +1 more source

Reflectance Adaptive Filtering Improves Intrinsic Image Estimation

, 2017
Separating an image into reflectance and shading layers poses a challenge for learning approaches because no large corpus of precise and realistic ground truth decompositions exists. The Intrinsic Images in the Wild~(IIW) dataset provides a sparse set of
Gehler, Peter V., Nestmeyer, Thomas
core   +1 more source