Results 61 to 70 of about 491,522 (274)

A new fractional Fourier transform based monopulse tracking radar processor [PDF]

, 2010
Conventional monopulse radar processors are used to track a target that appears in the look direction beam width. The distortion produced when additional targets appear in the look direction beam width can cause severe erroneous outcomes from the ...
Elgamel, Sherif A.E.H., Soraghan, J.J.
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

A stochastic signal processing method for removing a wind noise based on the wide sense digital filter in a low frequency sound measurement.

Journal of the Acoustical Society of Japan (E), 1994
As is well-known, in the measurement of low frequency sound, a main spectrum componentof the wind noise coexists almost within the same frequency bands as the lowfrequency sound. Accordingly, it is essentially difficult to eliminate this effect of windnoise only by using the analog filter based on the usual electrical cricuit.
Mitsuo Ohta, Shigeharu Miyata
openaire   +2 more sources

Investigating the impact of image content on the energy efficiency of hardware-accelerated digital spatial filters [PDF]

, 2019
Battery-operated low-power portable computing devices are becoming an inseparable part of human daily life. One of the major goals is to achieve the longest battery life in such a device.
Badii, Atta, Raval, Rajkumar K.
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Research status and prospect of UWB radar echo signal processing technology for mine rescue

Meikuang Anquan
Ultra-wideband (UWB) radar echo signal processing affects the accurate detection of life signals, which is a key prerequisite for the success of mine rescue operations.
Xuezhao ZHENG, Chaoyang SUN, Yuan HUANG, Wen DING, Yang MA, Qiang LI, Haowei MOU   +6 more
doaj   +1 more source

Auditory-inspired morphological processing of speech spectrograms: applications in automatic speech recognition and speech enhancement [PDF]

, 2012
New auditory-inspired speech processing methods are presented in this paper, combining spectral subtraction and two-dimensional non-linear filtering techniques originally conceived for image processing purposes.
A Rix, Ascensión Gallardo-Antolín, B Glasberg, B Moore, B Moore, C Martínez, C Peláez-Moreno, Carmen Peláez-Moreno, E Zwicker, E Zwicker, E Zwicker, F Jelinek, Francisco J. Valverde-Albacete, H Fastl, J Baker, J Beerends, Joyner Cadore, L Rabiner, L ten Bosch, M Florentine, Q Summerfield, R Gonzalez, R Meddis, R Meddis, R Patterson, S Davis, S Quackenbush, SS Stevens, T Irino, T Irino, TF Quatieri, TS Gunawan, W Jesteadt, Y Ephraim, Y Hu   +34 more
core   +2 more sources