Results 171 to 180 of about 7,588 (203)

Expression and Purification of the Mannose Recognition Domain of the FimH Adhesin. [PDF]

FEMS Microbiology Letters, 2000
Type 1 fimbriae have been shown to be specifically required for Escherichia coli colonisation and pathogenesis of the urinary tract. These structural organelles mediate specific adhesion to alpha-D-mannosides by virtue of the FimH adhesin. FimH is a two-domain protein in which the N-terminal domain contains the receptor-binding site and the C-terminal ...
Henrik Hasman, Mark A. Schembri, Per Klemm   +2 more
exaly   +6 more sources

Some of the next articles are maybe not open access.

Related searches:

Prodruggability of carbohydrates — oral FimH antagonists

Canadian Journal of Chemistry, 2016
The bacterial lectin FimH is a promising therapeutic target for the nonantibiotic prevention and treatment of urinary tract infections. In this communication, an ester prodrug approach is described to achieve oral bioavailability for FimH antagonists.
Schönemann, Wojciech, Kleeb, Simon, Dätwyler, Philipp, Schwardt, Oliver, Ernst, Beat   +4 more
openaire   +3 more sources

A Flow Cytometry-Based Assay for Screening FimH Antagonists

ASSAY and Drug Development Technologies, 2011
Urinary tract infections (UTIs), including cystitis and pyelonephritis, affect a large proportion of the population and account for significant medical costs. In more than 80% of UTIs, uropathogenic Escherichia coli (UPEC) is the causative pathogen.
Scharenberg, Meike, Abgottspon, Daniela, Cicek, Evelin, Jiang, Xiaohua, Schwardt, Oliver, Rabbani, Said, Ernst, Beat   +6 more
openaire   +4 more sources

FimH Antagonists: Phosphate Prodrugs Improve Oral Bioavailability

Journal of Medicinal Chemistry, 2016
The widespread occurrence of urinary tract infections has resulted in frequent antibiotic treatment, contributing to the emergence of antimicrobial resistance. Alternative approaches are therefore required. In the initial step of colonization, FimH, a lectin located at the tip of bacterial type 1 pili, interacts with mannosylated glycoproteins on the ...
Kleeb, Simon, Jiang, Xiaohua, Frei, Priska, Sigl, Anja, Bezençon, Jacqueline, Bamberger, Karen, Schwardt, Oliver, Ernst, Beat   +7 more
openaire   +4 more sources

Kinetic Properties of Carbohydrate–Lectin Interactions: FimH Antagonists

ChemMedChem, 2013
AbstractThe lectin FimH is terminally expressed on type 1 pili of uropathogenic Escherichia coli (UPEC), which is the main cause of urinary tract infections (UTIs). FimH enables bacterial adhesion to urothelial cells, the initial step of infection.
Scharenberg, Meike, Jiang, Xiaohua, Pang, Lijuan, Navarra, Giulio, Rabbani, Said, Binder, Florian, Schwardt, Oliver, Ernst, Beat   +7 more
openaire   +4 more sources

Mast cell phagocytosis of FimH-expressing enterobacteria.

The Journal of Immunology, 1994
Abstract Most studies of mast cells have been directed at their role in the pathophysiology of IgE-mediated allergic reactions with little recognition of their participation in bacterial infections. We report that mast cells can specifically bind FimH, a mannose-binding subunit on type 1 fimbriae expressed by Escherichia coli and ...
R, Malaviya, E A, Ross, J I, MacGregor, T, Ikeda, J R, Little, B A, Jakschik, S N, Abraham   +6 more
openaire   +2 more sources

Structural and Functional Characterization of the FimH Adhesin of Uropathogenic Escherichia coli and Its Novel Applications

Microbial Pathogenesis, 2021
Rezvan Moniri, Ahmad Khorshidimalahmadi
exaly  

D-Mannoside FimH Inhibitors as Non-Antibiotic Alternatives for Uropathogenic Escherichia coli

Antibiotics, 2021
Johan Fabian Galindo, Alfredo Montes-Robledo, Rosa Baldiris-Ávila   +2 more
exaly  

On-Cell Saturation Transfer Difference NMR for the Identification of FimH Ligands and Inhibitors

Bioorganic Chemistry, 2021
Paola Sperandeo, Cristina Airoldi, Sara Bertuzzi   +2 more
exaly  

FIMH MUTANT, COMPOSITIONS THEREWITH AND USE THEREOF

2021
GRIJPSTRA JAN, WEERDENBURG EVELINE MARLEEN, GEURTSEN JEROEN, FAE KELLEN CRISTHINA, FEITSMA LOURIS JAKOB   +4 more
openaire   +10 more sources