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First molecular detection of porcine rotavirus B (RVB) in Poland - case study and genome analysis. [PDF]

open access: yesPorcine Health Manag
Cybulski P   +4 more
europepmc   +1 more source
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Target Selectivity of FimH Antagonists

Journal of Medicinal Chemistry, 2012
Mannose-based FimH antagonists are considered new therapeutics for the treatment of urinary tract infections (UTIs). They prevent the adhesion of uropathogenic Escherichia coli (UPEC) to urothelial cell surfaces triggered by the lectin FimH, which is located at the tip of bacterial type 1 pili.
Meike, Scharenberg   +3 more
openaire   +2 more sources

Glycofullerene-AuNPs as multivalent ligands of DC-SIGN and bacterial lectin FimH: tuning nanoparticle size and ligand density.

Nanoscale, 2023
Glycoclusters have been extensively investigated for their inhibition of multivalent carbohydrate-protein interactions, which is often the first step for bacterial and viral pathogens to selectively bind their host cells.
Tao Wang   +4 more
semanticscholar   +1 more source

Cytokine profile in HTB-4 cells with respect to fimH, papC and hlyA expression in uropathogenic Escherichia coli invasion.

Future Microbiology, 2023
Background: In this study, uropathogenic Escherichia coli (UPEC) from pregnant and nonpregnant patients were characterized with respect to antimicrobial resistance (AMR) and expression of their virulence factors and cytokines elicited upon infection in ...
Snehashis Koley, M. Mukherjee
semanticscholar   +1 more source

FimH Antagonists: Phosphate Prodrugs Improve Oral Bioavailability

Journal of Medicinal Chemistry, 2016
The widespread occurrence of urinary tract infections has resulted in frequent antibiotic treatment, contributing to the emergence of antimicrobial resistance. Alternative approaches are therefore required. In the initial step of colonization, FimH, a lectin located at the tip of bacterial type 1 pili, interacts with mannosylated glycoproteins on the ...
Kleeb, Simon   +7 more
openaire   +3 more sources

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