Results 241 to 250 of about 13,264 (267)

Safety, pharmacokinetic, and pharmacodynamic study of sibofimloc, a novel FimH blocker in patients with active Crohn's disease

Journal of Gastroenterology and Hepatology, 2022
Expression of FimH adhesin by invasive Escherichia coli in the gastrointestinal tract of patients with Crohn's disease (CD) facilitates binding to epithelial glycoproteins and release of pro‐inflammatory cytokines.
W. Reinisch, X. Hébuterne, A. Buisson, S. Schreiber, P. Desreumaux, C. Primas, J. Paillarse, Gregoire Chevalier, C. Bonny   +8 more
semanticscholar   +1 more source

Prodruggability of carbohydrates — oral FimH antagonists

Canadian Journal of Chemistry, 2016
The bacterial lectin FimH is a promising therapeutic target for the nonantibiotic prevention and treatment of urinary tract infections. In this communication, an ester prodrug approach is described to achieve oral bioavailability for FimH antagonists.
Schönemann, Wojciech, Kleeb, Simon, Dätwyler, Philipp, Schwardt, Oliver, Ernst, Beat   +4 more
openaire   +2 more sources

Elucidating novel antibacterial compounds from the NPASS database against the FimH lectin domain for the treatment of urinary tract infections: an in-silico study

Journal of Biomolecular Structure and Dynamics, 2022
The increase in multidrug-resistant pathogens in urinary tract infections (UTIs) among communities and hospitals threatens our ability to treat these common pathogens.
Mrtatha K Al-Zrkani, Rafid A Abdulkareem, D. Al-Fahad, Marwah Al Shouber, A. Nasr, Ahmad Al-Khdhairawi   +5 more
semanticscholar   +1 more source

Evaluation of genes involved in the binding and invasion of Klebsiella pneumoniae including fimH-1, entB, iutA, rmpA and cnf-1 genes in patients with urinary tract infection

Reviews and Research in Medical Microbiology, 2022
Introduction: Klebsiella pneumoniae is a member of the Enterobacteriaceae that causes nosocomial infections. The aim of this study was to identify the binding, invasive and pathogenic profiles of K.
Bahman Yousefi, A. Abdolshahi, M. Dadashpour, Daryoush Pahlevan, H. Ghaffari, M. Eslami   +5 more
semanticscholar   +1 more source

Discovery and Application of FimH Antagonists

2014
Just like bacteria need to be mobile to seek for nutrients, bacteria need to adhere to biotic and abiotic surfaces to enable their progression. Most bacteria regulate the expression of a multitude of fimbrial adhesins that display varying specificities and architectures.
Gouin, Sébasties G, Roos, Goedele, Bouckaert, J.   +2 more
openaire   +2 more sources

Kinetic Properties of Carbohydrate–Lectin Interactions: FimH Antagonists

ChemMedChem, 2013
AbstractThe lectin FimH is terminally expressed on type 1 pili of uropathogenic Escherichia coli (UPEC), which is the main cause of urinary tract infections (UTIs). FimH enables bacterial adhesion to urothelial cells, the initial step of infection.
Scharenberg, Meike, Jiang, Xiaohua, Pang, Lijuan, Navarra, Giulio, Rabbani, Said, Binder, Florian, Schwardt, Oliver, Ernst, Beat   +7 more
openaire   +3 more sources

Facile Synthesis of FimH Antagonist and Its Analogues: Simple Entry to Complex C-Mannoside Inhibitors of E. coli Adhesion.

ACS Medicinal Chemistry Letters
Synthesizing FimH antagonists is challenging because of their densely functionalized and stereochemically complex C-mannoside structures, resulting in low yields and lengthy processes.
Zhaobo Zhou, Renpeng Tang, Ya Fang, Tinghong Lv, Jian Liu, Xiaolei Wang   +5 more
semanticscholar   +1 more source

Mast cell phagocytosis of FimH-expressing enterobacteria.

The Journal of Immunology, 1994
Abstract Most studies of mast cells have been directed at their role in the pathophysiology of IgE-mediated allergic reactions with little recognition of their participation in bacterial infections. We report that mast cells can specifically bind FimH, a mannose-binding subunit on type 1 fimbriae expressed by Escherichia coli and other ...
R, Malaviya, E A, Ross, J I, MacGregor, T, Ikeda, J R, Little, B A, Jakschik, S N, Abraham   +6 more
openaire   +2 more sources

A Flow Cytometry-Based Assay for Screening FimH Antagonists

ASSAY and Drug Development Technologies, 2011
Urinary tract infections (UTIs), including cystitis and pyelonephritis, affect a large proportion of the population and account for significant medical costs. In more than 80% of UTIs, uropathogenic Escherichia coli (UPEC) is the causative pathogen.
Scharenberg, Meike, Abgottspon, Daniela, Cicek, Evelin, Jiang, Xiaohua, Schwardt, Oliver, Rabbani, Said, Ernst, Beat   +6 more
openaire   +3 more sources

Development of an aggregation assay to screen FimH antagonists

Journal of Microbiological Methods, 2010
Alpha-D-mannopyranosides are potent FimH antagonists, which inhibit the adhesion of Escherichia coli to highly mannosylated uroplakin Ia on the urothelium and therefore offer an efficient therapeutic opportunity for the treatment and prevention of urinary tract infection. For the evaluation of the therapeutic potential of FimH antagonists, their effect
Abgottspon, Daniela, Rölli, Gina, Hosch, Lucie, Steinhuber, Andrea, Jiang, Xiaohua, Schwardt, Oliver, Cutting, Brian, Smiesko, Martin, Jenal, Urs, Ernst, Beat, Trampuz, Andrej   +10 more
openaire   +3 more sources