Results 61 to 70 of about 793,305 (259)
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Pakistan Journal of Applied EconomicsThe main purpose of this study is to assess the impact of changes in corporate governance practices, introduced by the Companies Act 2017 (which replaced the Companies Ordinance, 1984), on the financial performance of non-financial sector companies in ...
Imtiaz ARIF, Ehsan MOIN, Jahanzaib ALVI
doaj
FUDMA Journal of Accounting and Finance Research (FUJAFR)Corporate governance is vital for transparency, accountability, and efficiency in organizational management. A key aspect of corporate governance is agency monitoring, which entails costs incurred to oversee managerial actions and align them with ...
Patrick Orbanga Awuhe +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
How Corporate Social Responsibility Boosts Corporate Financial and Non-financial Performance: The Moderating Role of Ethical Leadership. [PDF]
Front Psychol, 2022 Bouichou SI, Wang L, Zulfiqar S.
europepmc +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Social disclosure practices and financial performance: evidence from non-financial firms in Nigeria
FUDMA Journal of Accounting and Finance Research (FUJAFR)Purpose: Companies in developing nations, particularly Nigeria, have benefited financially at the expense of their workers by failing to meet their operational demands and properly disclosing this information in their annual reports.
Jamiu Alabere Abdulrasheed +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin +12 more
wiley +1 more source
Influences of implementing the learning organisation on companies` financial and non-financial performances [PDF]
Managing Global Transitions, 2010 The learning organisation (LO) concept as one of the numerous management tools available has been significantly gaining in popularity around the globe. Yet few models have been implemented to assess the lo’s influences on companies’ non-financial and financial performances.
openaire +2 more sources