Results 71 to 80 of about 415,149 (259)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Carbon emissions trading system and corporate financial decisions: evidence from China

Carbon Management
Using a staggered difference-in-differences (DID) approach on a sample of Chinese A-share listed firms, we find that the carbon emissions trading system (ETS) increases financial distress risk for emission-regulated firms, prompting them to adopt more ...
Yuxuan Wang, Chan Lyu
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

IMPACT OF MICROFINANCE INSTITUTIONS ON FINANCIAL LITERACY IN NORTH CENTRAL GEO-POLITICAL ZONE NIGERIA

Copernican Journal of Finance & Accounting, 2021
Inclusive financial literacy through Microfinance Institutions activities is becoming a policy issue in both developed and developing nations of the world as it has been perceived as a veritable tool for economic development.
Ibrahim Majeed Ajibola, Daud Omotosho Saheed, Lukman Adedoyin   +2 more
doaj  

Identifying the Components of Complexity and Biases Cognitive Related to the Financial Decisions of Academic Entrepreneurs with the Qualitative Research Approach of Grand Theory [PDF]

پژوهش‌های کاربردی روانشناختی
The purpose of this research was to identify the components of complexity and cognitive biases that are associated with the financial decisions of academic entrepreneurs.
Mohammad Mahdi Babaei, Mitra Ezati, Hasan Mahjoob Eshrat Abadi, Vahid Mehrabani   +3 more
doaj   +1 more source

The persistence of cognitive biases in financial decisions across economic groups. [PDF]

Sci Rep, 2023
Ruggeri K, Ashcroft-Jones S, Abate Romero Landini G, Al-Zahli N, Alexander N, Andersen MH, Bibilouri K, Busch K, Cafarelli V, Chen J, Doubravová B, Dugué T, Durrani AA, Dutra N, Garcia-Garzon E, Gomes C, Gracheva A, Grilc N, Gürol DM, Heidenry Z, Hu C, Krasner R, Levin R, Li J, Messenger AME, Miralem M, Nilsson F, Oberschulte JM, Obi T, Pan A, Park SY, Pascu DS, Pelica S, Pyrkowski M, Rabanal K, Ranc P, Mekiš Recek Ž, Symeonidou A, Tutuska OS, Vdovic M, Yuan Q, Stock F.   +41 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

THE INFLUENCE OF FINANCIAL INCLUSION AND FINANCIAL BEHAVIOR ON INVESTMENT DECISIONS

Journal of Management Small and Medium Enterprises (SME's)
The research aims to assess the influence of financial inclusion and financial behavior on investment decisions through a survey of MSMEs in West Java.
Yusup Maulana Nur Shidik, Aceng Kurniawan   +1 more
doaj   +1 more source