Results 61 to 70 of about 3,679,025 (298)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

open access: yesMolecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor   +2 more
wiley   +1 more source

Financial Technology: Review of Trends, Approaches and Management

open access: yesMathematics, 2020
Technological innovation and digitization have posed a challenge to the financial sector globally. Fintech is the term used to designate the application of new technologies to financial services.
Emilio Abad-Segura   +3 more
doaj   +1 more source

New quality of financial institutions and business management [PDF]

open access: yes, 2020
Economic processes in the world are characterized by a high level of dynamism, change and innovative approaches to addressing key issues in nowadays.
Kraus, Kateryna   +2 more
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

ANALYZING OPERATIONAL AND FINANCIAL PERFORMANCE ON THE FINANCIAL TECHNOLOGY (FINTECH) FIRM (Case Study on Samsung Pay) [PDF]

open access: yes, 2017
This study aims to analyze the operational and financial performance of Samsung Pay at United States in the year of 2015. Operational performances consist of availability, security, and effectiveness and usability of Samsung Pay.
ALIMIRRUCHI, Wahyu, KISWARA, Endang
core  

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

Performance of interest rate rules under credit market imperfections [PDF]

open access: yes, 2003
The stabilization effects of Taylor rules are analyzed in a limited participation framework with and without credit market imperfections in capital goods production.
Blas Pérez, Beatriz de
core   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Investigating the determinants and growth of financial technology depth of penetration among the heterogeneous Africa economies

open access: yesCogent Economics & Finance, 2020
The widespread financial exclusion in Africa despite the continent’s high adoption of financial technology (Fintech) suggests that there is a gap between Fintech’s adoption and its actual usefulness.
Tochukwu Timothy Okoli   +1 more
doaj   +1 more source

Home - About - Disclaimer - Privacy