Results 41 to 50 of about 1,262,485 (305)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Mechanisms for Producing Primordial Black Holes from Inflationary Models beyond Fine-Tuning

Universe
In this study, we present an analysis of the fine-tuning required in various inflationary models in order to explain the production of Primordial Black Holes (PBHs).
Ioanna Stamou
doaj   +1 more source

Fine-tuning of the allosteric response.

, 2018
Fine-tuning of allosteric response at the NAD functional site of the NAD-dependent malic enzyme can be achieved by varying composition of the perturbed site 1. The free energy changes (kcal/mol) at the NAD functional site are shown.
Wei-Ven Tee (5410859), Enrico Guarnera (2256904), Igor N. Berezovsky (193014)   +2 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Advancing privacy-aware machine learning on sensitive data via edge-based continual µ-training for personalized large models

Machine Learning: Science and Technology
This paper introduces an innovative method for fine-tuning a large multi-label model for abnormality detection, utilizing a smaller trainer and advanced knowledge distillation techniques.
Zhaojing Huang, Leping Yu, Luis Fernando Herbozo Contreras, Kamran Eshraghian, Nhan Duy Truong, Armin Nikpour, Omid Kavehei   +6 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Fine-tuning Audio Spectrogram Transformer with Task-aware Adapters for Sound Event Detection

, 2023
In this paper, we present a task-aware fine-tuning method to transfer Patchout faSt Spectrogram Transformer (PaSST) model to sound event detection (SED) task.
Lin Liu (74495), Ian McLoughlin (10759890), Yan Song (119387), Jin Li (119007), Kang Li (107509), Li-Rong Dai (402793)   +5 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source