Results 51 to 60 of about 1,764,417 (289)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Probability in Fine-Tuning Design Arguments [PDF]

, 2007
This paper examines probabilistic versions of the fine-tuning argument for design (FTA), with an emphasis on the interpretation of the probability statements involved in such arguments. Three categories of probability are considered: physical, epistemic,
Staley, Kent, Kent W. Staley
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Mechanisms for Producing Primordial Black Holes from Inflationary Models beyond Fine-Tuning

Universe
In this study, we present an analysis of the fine-tuning required in various inflationary models in order to explain the production of Primordial Black Holes (PBHs).
Ioanna Stamou
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Advancing privacy-aware machine learning on sensitive data via edge-based continual µ-training for personalized large models

Machine Learning: Science and Technology
This paper introduces an innovative method for fine-tuning a large multi-label model for abnormality detection, utilizing a smaller trainer and advanced knowledge distillation techniques.
Zhaojing Huang, Leping Yu, Luis Fernando Herbozo Contreras, Kamran Eshraghian, Nhan Duy Truong, Armin Nikpour, Omid Kavehei   +6 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Fine-Tuning in Light of Multiverse Confirmation. [PDF]

, 2023
Fine-tuning for life is extraordinarily unlikely given random chance but substantially more likely given the existence of a God. The fine-tuning argument framed in Bayesian probability, claims that because fine-tuning for life is more likely given the ...
Buras, Benjamin.
core