Results 51 to 60 of about 2,403,325 (304)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Mechanisms for Producing Primordial Black Holes from Inflationary Models beyond Fine-Tuning

Universe
In this study, we present an analysis of the fine-tuning required in various inflationary models in order to explain the production of Primordial Black Holes (PBHs).
Ioanna Stamou
doaj   +1 more source

Performance of Fine-Tuned Large Language Models in Patent Text Mining [PDF]

Nongye tushu qingbao xuebao
[Purpose/Significance] The use of large language models (LLMs) for patent text mining has become a major research topic in recent years. However, existing studies mainly focus on the application of LLMs to specific tasks, and there is a lack of ...
LYU Lucheng, ZHOU Jian, SUN Wenjun, ZHAO Yajuan, HAN Tao
doaj   +1 more source

A Comprehensive Performance Analysis of Transfer Learning Optimization in Visual Field Defect Classification

Diagnostics, 2022
Numerous research have demonstrated that Convolutional Neural Network (CNN) models are capable of classifying visual field (VF) defects with great accuracy.
Masyitah Abu, Nik Adilah Hanin Zahri, Amiza Amir, Muhammad Izham Ismail, Azhany Yaakub, Said Amirul Anwar, Muhammad Imran Ahmad   +6 more
doaj   +1 more source

Measuring the Instability of Fine-Tuning

Proceedings of the 61st Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers), 2023
Fine-tuning pre-trained language models on downstream tasks with varying random seeds has been shown to be unstable, especially on small datasets. Many previous studies have investigated this instability and proposed methods to mitigate it. However, most studies only used the standard deviation of performance scores (SD) as their measure, which is a ...
Yupei Du, Dong Nguyen 0002
openaire   +4 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Advancing privacy-aware machine learning on sensitive data via edge-based continual µ-training for personalized large models

Machine Learning: Science and Technology
This paper introduces an innovative method for fine-tuning a large multi-label model for abnormality detection, utilizing a smaller trainer and advanced knowledge distillation techniques.
Zhaojing Huang, Leping Yu, Luis Fernando Herbozo Contreras, Kamran Eshraghian, Nhan Duy Truong, Armin Nikpour, Omid Kavehei   +6 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source