Results 61 to 70 of about 1,764,417 (289)
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
Developmental Cognitive Neuroscience, 2023 N1 tuning to words, a neural marker of visual word recognition, develops by an interaction between age and ability. The development of N1 tuning to a second learnt print is unclear.
Shuting Huo +4 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
, 2020 "If the physical constants, initial conditions, or laws of nature in our universe had been even slightly different, then the evolution of life would have been impossible.
Waller, Jason 1980-
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Performance of Fine-Tuned Large Language Models in Patent Text Mining [PDF]
Nongye tushu qingbao xuebao[Purpose/Significance] The use of large language models (LLMs) for patent text mining has become a major research topic in recent years. However, existing studies mainly focus on the application of LLMs to specific tasks, and there is a lack of ...
LYU Lucheng, ZHOU Jian, SUN Wenjun, ZHAO Yajuan, HAN Tao
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Fine-tuning of the allosteric response.
, 2018 Fine-tuning of allosteric response at the NAD functional site of the NAD-dependent malic enzyme can be achieved by varying composition of the perturbed site 1. The free energy changes (kcal/mol) at the NAD functional site are shown.
Wei-Ven Tee (5410859) +2 more
core +1 more source
Fine-tuning protein language models boosts predictions across diverse tasks
Nature CommunicationsPrediction methods inputting embeddings from protein language models have reached or even surpassed state-of-the-art performance on many protein prediction tasks.
Robert Schmirler +2 more
doaj +1 more source