Results 61 to 70 of about 1,262,485 (305)

Fine-tuning structural RNA alignments in the twilight zone

, 2010
Bremges A, Schirmer S, Giegerich R. Fine-tuning structural RNA alignments in the twilight zone. BMC Bioinformatics. 2010;11(1): 222.Background A widely used method to find conserved secondary structure in RNA is to first construct a multiple sequence ...
Bremges Andreas, Schirmer, Stefanie, Stefanie Schirmer, Schirmer Stefanie, Bremges, Andreas ; https://orcid.org/, Robert Giegerich, Giegerich, Robert, Giegerich Robert, Andreas Bremges   +8 more
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Neural specialization of print processing in second language learning: A longitudinal ERP study of Chinese children learning English

Developmental Cognitive Neuroscience
The N1 component of event-related potentials (ERP) reflects print tuning and lexicality effects. Previous studies have shown that for a second learned writing system, tuning and lexical effects are associated with age and ability.
Xin Huang, Jai Dellosa Ariza, Shuting Huo, Jason Chor Ming Lo, Catherine McBride, Urs Maurer   +5 more
doaj   +1 more source

Fine-tuned model and USPTO data used in fine-tuning

Fine-tuned model and USPTO data used in fine ...
Qianxiang Ai (18261997)
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Zasada szczególnego dostrojenia w kontekście układów z chaosem deterministycznym

Zagadnienia Filozoficzne w Nauce, 2008
From the beginning of the deterministic chaos research, the unpredictability has been its central theme. Interesting questions arise here: What are the consequences of chaos for the fine tuned processes? Are there fine tuning systems in reality?
Bartłomiej Brus, Marek Szydłowski
doaj  

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

PARAMETER EFFICIENT FINE-TUNING AND OVERFITTING IN GPT LARGE LANGUAGE MODELS: A METRIC-BASED COMPARISON

Електроніка та інформаційні технології
Background. Building upon previous research, this study conducts an exploration into Large Language Models (LLMs), with an emphasis on the fine-tuning and assessment of LLaMA-3.1 for instructional tasks. LLaMA-3.1, which is a new generation model and has
Bohdan Pavlyshenko, Ivan Bulka
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source