Results 61 to 70 of about 462,525 (261)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Chromatographic identification of leaf color characteristics on fine-flavor and bulk cacao as selection indicator

Coffee and Cocoa Research Journal, 2016
A problem encountered in plant breeding process to determine bean color quality of fine-flavor cocoa is a long selection period. Preliminary results indicated that the fine-flavor cocoa has a low color reflectance than bulk cocoa.
Indah Anita Sari, Bayu Setyawan, Marcelinus A.S. Adhiwibawa, Agung Wahyu Susilo   +3 more
doaj   +1 more source

Impact of fine materials on the saturated and unsaturated behavior of silty sand soil

Ain Shams Engineering Journal, 2020
The current study aims to investigate the influence of the addition of fine materials on the engineering properties of silty sand soil. An intensive laboratory study of saturated and unsaturated silty sand soil treated with different percentages of fine ...
Abdulrahman Aldaood
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Dynamics of fine root biomass and morphology of European beech (Fagus sylvatica L.) forest stands along a soil moisture gradient

Forest Ecosystems
Increasing evidence suggests that fine roots are particularly sensitive to environmental changes, making them essential in responding and adapting forest ecosystems to climate change.
Alexandra Koller, Alina Azekenova, Patrick Wordell-Dietrich, Robin Schäfferling, Lilli Zeh, Stefan Julich, Karsten Kalbitz, Karl-Heinz Feger, Goddert von Oheimb   +8 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Microscopic mechanism of content of fine particles affecting seepage erosion law

Yantu gongcheng xuebao
Exploring the transport characteristics of fine particles is of great engineering significance for clarifying the law of seepage erosion, as the content of fine particles will directly affect the resistance of soils to erodibility.
LIANG Yue 1, 2, 3, RAN Yuxing 1 , XU Bin 1, 2, 3, ZHANG Xinqiang 4, HE Huiru 1
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source