Results 51 to 60 of about 163,887 (300)

Aberrant fronto-striatal connectivity and fine motor function in schizophrenia

, 2019
: Abnormal fine motor function is a frequent finding in schizophrenia and has been linked to structural and functional brain alterations. However, whether fine motor function is related to functional alterations within the motor system remains unclear ...
Parizel, Paul M., Parizel, Paul M, Morrens, Manuel, Viher, Petra, van Hecke, Wim, Sabbe, Bernard, Walther, Sebastian, Docx, Lise, Federspiel, Andrea, Viher, Petra V.   +9 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Neuropathophysiological potential of Guillain-Barré syndrome anti-ganglioside-complex antibodies at mouse motor nerve terminals [PDF]

, 2011
Objectives:  Anti-ganglioside antibodies are present in approximately half of Guillain–Barré syndrome (GBS) patients. Recently, it has been shown that a considerable proportion of these patients has serum antibodies against antigenic epitopes formed by a
Susumu Kusunoki, Tio-Gillen, Anne P., Plomp, J.J., Kusunoki, Susumu, Tio-Gillen, A.P., Willison, H.J., Broos, Ludo A.M., Ueda, M., Mark L. Kuijf, Ludo A. M. Broos, Kuijf, Mark L., Jacobs, B.C., Greenshields, Kay N., Jacobs, Bart C., Zitman, F.M.P., Hugh J. Willison, Anne P. Tio-Gillen, Masami Ueda, Kuijf, M.L., Jaap J. Plomp, Kusunoki, S., Greenshields, K.N., Plomp, Jaap J., Femke M. P. Zitman, Broos, L.A.M., Kay N. Greenshields, Ken-ichi Kaida, Willison, Hugh J., Bart C. Jacobs, Kaida, Ken Ichi, Kaida, K.I., Ueda, Masami, Zitman, Femke M.P.   +32 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Permainan Edukatif Kardus Bekas untuk Mengembangkan Motorik Halus Anak Usia Dini

Jurnal Pelita PAUD
This research is an experimental study to analyze the improvement of fine motor skills in early childhood. The subjects of this study were children aged 5-6 years, the question used was observation.
Aisyah, Jahju Hartanti, Titah Kinasih, Yanita Dwi Masita   +3 more
doaj   +1 more source

Comparison of Motor Proficiency and Functional Ambulation in Duchenne Muscular Dystrophy With Healthy Peers

, 2020
Aims:The study was aimed to investigate the difference between boys with Duchenne muscular dystrophy (DMD) and healthy peers in terms of gross and fine motor proficiency, and determine the relationship between motor proficiency and ambulation.
Yıldız, Şulenur, Karaduman, Aynur Ayşe, AKEL, BURCU SEMİN, Tunca Yılmaz, Öznur, Şahin, Sedef, Bulut, Numan   +5 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Association of physical activity and fine motor performance in individuals with type 2 diabetes mellitus and/or non-alcoholic fatty liver disease

Annals of Medicine, 2023
Background Fine motor performance may serve as an early warning sign for reduced cognitive function. Physical activity can help preserve cognitive function; however, the relationship between fine motor performance and physical activity is not well ...
Ali A. Weinstein, Dung Ngo, Leyla de Avila, Jillian K. Price, Pegah Golabi, Patrick Austin, Carey Escheik, Lynn H. Gerber, Zobair M. Younossi   +8 more
doaj   +1 more source