Results 61 to 70 of about 2,358,245 (262)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Association between reported ADHD symptom and motor development delay in preschool children

Frontiers in Pediatrics
ObjectiveTo explore whether the motor developmental level is associated with the attention deficit/hyperactivity disorder (ADHD) symptoms severity reported by parents in preschool children.MethodsPreschool children aged 4–6 years old with the chief ...
Zhijun Cui, Shijie Li, Aimin Liang, Hongmei Huang, Xin Ni   +4 more
doaj   +1 more source

History of the Ohio Bureau of Motor Vehicles

, 2001
Title from caption (viewed Mar.
Ohio. Bureau of Motor Vehicles.
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Cognitive and motor disturbances in depression: insights from comprehensive behavioral assessments

Frontiers in Psychiatry
BackgroundDepression affects not only mood and reward processing, but also motor and cognitive functioning, leading to psychomotor disturbances crucial for diagnosis, prognosis, and treatment.
Ioanna Douka, Marit F. L. Ruitenberg, Marit F. L. Ruitenberg, Kamile Weischedel, Carlos Phouthavongsay, Sara L. Weisenbach, Jos N. van der Geest, Brian J. Mickey, Vincent Koppelmans   +8 more
doaj   +1 more source

Fine motor skills predict maths ability better than they predict reading ability in the early primary school years

Frontiers in Psychology, 2016
Fine motor skills have long been recognised as an important foundation for development in other domains. However, more precise insights into the role of fine motor skills, and their relationships to other skills in mediating early educational ...
Nicola J. Pitchford, Chiara ePapini, Laura A. Outhwaite, Anthea eGulliford   +3 more
doaj   +1 more source

Domain-specific skills, but not fine-motor or executive function, predict later arithmetic and reading in children

, 2022
Fine motor skills and executive function are two examples of domain-general skills. Both are correlates of arithmetic and reading ability, and have been identified as predictors of school readiness.
Hulme, Charles, Pritchard, Verena E, Malone, Stephanie A   +2 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Fine motor skills predict expressive, but not receptive, language abilities in minimally verbal autistic adults

Frontiers in Language Sciences
IntroductionPrevious research suggests that the motor system plays an important role in spoken language development for children and adolescents with autism spectrum disorder (ASD).
Meredith Pecukonis, Meredith Pecukonis, Paige Hickey Townsend, Paige Hickey Townsend, Paige Hickey Townsend, Laura Sarnie, Chakameh Jafari, Nataliya Kosmyna, Nishat Protyasha, James Williamson, Sophia Yuditskaya, Pattie Maes, Thomas F. Quatieri, Christopher J. McDougle, Christopher J. McDougle, Maria Mody, Maria Mody, Maria Mody, Lisa Nowinski   +18 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source