Results 111 to 120 of about 4,153 (212)

Finerenone in Heart Failure—A Novel Therapeutic Approach

International Journal of Molecular Sciences
This review will discuss heart failure, introduce a new drug finerenone, and discuss clinical studies with a focus on its effects on heart failure. Heart failure is a condition or syndrome characterized by an impairment of the pumping ability of the heart, thus no longer keeping up with the demands of the body. There are several types of heart failure;
Amalie Holst-Hansen, Daniela Grimm, Markus Wehland   +2 more
openaire   +3 more sources

Finerenone Alleviates Over-Activation of Complement C5a-C5aR1 Axis of Macrophages by Regulating G Protein Subunit Alpha i2 to Improve Diabetic Nephropathy

Cells
Diabetic nephropathy (DN), one of the most common complications of diabetes mellitus (DM), accounts for a major cause of chronic kidney disease (CKD) worldwide, with a complicated pathogenesis and limited effective strategies nowadays.
Zi-Han Li, Zi-Jun Sun, Sydney C. W. Tang, Ming-Hui Zhao, Min Chen, Dong-Yuan Chang   +5 more
doaj   +1 more source

Finerenone and Atrial Fibrillation in Heart Failure A Secondary Analysis of the FINEARTS-HF Randomized Clinical Trial [PDF]

IMPORTANCE Heart failure (HF) with mildly reduced or preserved ejection fraction and atrial fibrillation (AF) are closely intertwined. OBJECTIVE To examine the efficacy and safety of the nonsteroidal mineralocorticoid receptor antagonist finerenone in ...
Amarante, Flaviana, Bauersachs, Johann, Brinker, Meike, Chioncel, Ovidiu, Claggett, Brian L., Comin-Colet, Josep, Desai, Akshay S., Filippatos, Gerasimos, Henderson, Alasdair D., Jhund, Pardeep S., Lam, Carolyn S.P., Lay-Flurrie, James, Matsumoto, Shingo, McMurray, John J.V., Pitt, Bertram, Scheerer, Markus Florian, Schou, Morten, Senni, Michele, Shah, Sanjiv J., Solomon, Scott D., Vaduganathan, Muthiah, Voors, Adriaan A., Zannad, Faiez, Zieroth, Shelley   +23 more
core   +1 more source

Non-Steroidal Mineralocorticoid Receptor Antagonists: A Paradigm Shift in the Management of Diabetic Nephropathy

Kidney & Blood Pressure Research
Background: Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease worldwide. The management of DKD relies on controlling glycemia and blood pressure levels, as well as reducing proteinuria.
Justine Huart, François Jouret
doaj   +1 more source

Hyperkalaemia szívelégtelenségben. Új kezelési lehetőségek a láthatáron = Hyperkalemia in heart failure. New treatments on the horizon [PDF]

, 2018
Dékány, Miklós, Kiss, Róbert Gábor, Nyolczas, Noémi, Szabó, Márta, Vágány, Dénes   +4 more
core   +1 more source

Finerenone versus spironolactone in patients with chronic kidney disease and type 2 diabetes: a target trial emulation

Nature Communications
The comparative effectiveness of finerenone and spironolactone in chronic kidney disease (CKD) with type 2 diabetes (T2D) remains unclear. Here we show, using a target trial emulation on global real-world data from TriNetX, outcomes among 2268 propensity
Chung-An Wang, Hsuan-Wen Lai, Jui-Yi Chen, Wei-Jie Wang, Li-Chun Lin, Yen-Ling Chiu, Chung-Yi Cheng, Vin-Cent Wu   +7 more
doaj   +1 more source

Finerenone: a breakthrough mineralocorticoid receptor antagonist for heart failure, diabetes and chronic kidney disease

The Egyptian Heart Journal
Background Aldosterone is categorized as a mineralocorticoid hormone produced in the zona glomerulosa of the adrenal cortex. Aldosterone has considerable action in sodium and water retention along with cardiac remodeling, promoting fibrosis and these ...
Akshyaya Pradhan, Umesh Chandra Tripathi
doaj   +1 more source

CVOT summit report 2024: new cardiovascular, kidney, and metabolic outcomes [PDF]

The 10th Cardiovascular Outcome Trial (CVOT) Summit: Congress on Cardiovascular, Kidney, and Metabolic Outcomes was held virtually on December 5–6, 2024.
Almandoz, J, Anderson, L, Barnard-Kelly, K, Battelino, T, Blüher, M, Busetto, L, Catrinou, D, Ceriello, A, Cos, X, Danne, T, Dayan, CM, Del Prato, S, Fernández-Fernández, B, Fioretto, P, Forst, T, Gavin, JR, Giorgino, F, Groop, PH, Harsch, IA, Heerspink, HJL, Heinemann, L, Ibrahim, M, Jadoul, M, Jarvis, S, Ji, L, Kanumilli, N, Kosiborod, M, Landmesser, U, Macieira, S, Mankovsky, B, Marx, N, Mathieu, C, McGowan, B, Milenkovic, T, Moser, O, Müller-Wieland, D, Papanas, N, Patel, DC, Pfeiffer, AFH, Rahelić, D, Rodbard, HW, Rydén, L, Schaeffner, E, Schnell, O, Spearman, CW, Standl, E, Stirban, A, Tacke, F, Topsever, P, Van Gaal, L   +49 more
core  

Efficacy and safety of mineralocorticoid receptor antagonists for patients with heart failure and diabetes mellitus: a systematic review and meta-analysis [PDF]

, 2016
Chao Zheng, Chun-Ying Li, Hai-Min Yin, Jin-Jue Zheng, Liang-Xue Wang, Meng-Di Fan, Meng-Die Chen, Ning-Yu Cai, Si-Si Dong, Su-Ping Gu, Xin-He Zhou   +10 more
core   +1 more source

New and Convergent Synthesis of Finerenone

Organic Preparations and Procedures International
New and Convergent Synthesis of ...
Junhao Chen, Yongjun Mao, Wei Liu, Baolin Xu, Huimin Ren   +4 more
openaire   +1 more source