Results 111 to 120 of about 22,351 (243)

Central Versus Peripheral Drug Exposure Ratio, a Key Differentiator for Siponimod Over Fingolimod?

Neurology and Therapy, 2023
Introduction Siponimod, a potent and selective sphingosine-1-phosphate (S1P1,5) agonist, is the only therapeutic agent that has shown efficacy against disability progression, decline in cognitive processing speed, total brain volume loss, gray matter ...
Marc Bigaud, Pamela Ramseier, Sarah Tisserand, Meike Lang, Beatrice Urban, Christian Beerli, Göril Karlsson   +6 more
doaj   +1 more source

Health Literacy and Unmet Needs in Patients With Multiple Sclerosis: A Cross‐Sectional Study

Journal of Clinical Nursing, EarlyView.
ABSTRACT Aims To identify a correlation between unmet needs and HL levels in people with Multiple Sclerosis (pwMS) and to evaluate how sociodemographic characteristics influence HL levels and unmet needs. Design A cross‐sectional study. Methods The study was conducted using a questionnaire including the HLS19‐Q12 to assess HL and the Long‐term Unmet ...
Francesco Pastore, Barbara Forastefano, Valentina Simonetti, Tommaso Guerra, Giancarlo Cicolini, Pietro Iaffaldano, Dania Comparcini   +6 more
wiley   +1 more source

Identification of Novel Therapeutic Agent Candidates Through High Throughput Screening With Chemical Library Based on Molecular Subclassification in Canine Histiocytic Sarcoma Cell Lines

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Effective chemotherapy for canine histiocytic sarcoma (CHS) has yet to be established. In our previous study, CHS cell lines were subclassified into two groups based on their gene expression profiles: Group A and Group B. This study aimed to identify novel therapeutic agents that are effective against each CHS subgroup, and we performed high ...
Hiroki Sakuma, Hirotaka Tomiyasu, Mari Takamiya, Yuko Goto‐Koshino, Atsushi Tsukamoto, Makoto Bonkobara, Masaru Okuda   +6 more
wiley   +1 more source

Toxicidad hepática por fingolimod

, 2023
We present the case of a patient with a history of multiple sclerosis under chronic fingolimod treatment who presents abdominal pain associated with jaundice associated with transaminitis that by biopsy is associated with late hepatotoxicity due to ...
Arenas Peña, Gabriel José, Oliveros Araujo, Karen Vanessa, Theran Leon, Juan Sebastian, Esteban Badillo, Laura Yibeth, Andrés Dulcey, Luis   +4 more
core  

A rare presentation of atypical demyelination: tumefactive multiple sclerosis causing Gerstmann's syndrome [PDF]

, 2014
r.
Kelly Pegoretti Baruteau, Gnanasambandam, Sakthivel, Schmierer, Klaus, Zane Jaunmuktane, Gnanapavan, Sharmilee, Gnanapavan, S, Klaus Schmierer, Sharmilee Gnanapavan, Gnanasambandam, S, Schmierer, K, Baruteau, KP, Jaunmuktane, Z, Jaunmuktane, Zane, Pegoretti Baruteau, Kelly, Sakthivel Gnanasambandam   +14 more
core   +1 more source

Fingolimod as a potent anti-Staphylococcus aureus: pH-dependent cell envelope damage and eradication of biofilms/persisters

BMC Microbiology
Background The urgent need for new antibacterial drugs has driven interest in repurposing therapies to combat Gram-positive biofilms and persisters.
Yongpeng Shang, Yu Huang, Qingyin Meng, Zhijian Yu, Zewen Wen, Fangyou Yu   +5 more
doaj   +1 more source

The Effects of the S1P Receptor Agonist Fingolimod (FTY720) on Central and Peripheral Myelin in Twitcher Mice

Biomedicines
Krabbe’s disease (KD) is caused by mutations in the lysosomal enzyme galactocerebrosidase and is associated with psychosine toxicity. The sphingosine 1-phosphate receptor (S1PR) agonist fingolimod (FTY720) attenuates psychosine-induced cell death of ...
Sibylle Béchet, Kumlesh K. Dev
doaj   +1 more source

Sphingosine‐1‐Phosphate Receptor 1 Promotes Ovarian Cancer Tumorsphere Proliferation and Metastasis

International Journal of Cancer, Volume 159, Issue 3, Page 768-781, 1 August 2026.
In high‐grade serous ovarian cancer, malignant ascites frequently arise as ovarian cancer cells shed from the primary tumor and aggregate into tumorspheres, severely limiting treatment success. To date, little is known about the mechanisms governing tumorsphere endurance and metastasis within the ascites once formed.
Núria Gendrau‐Sanclemente, Agnès Figueras, Ferran Medina‐Jover, Juan A. Marín‐Jiménez, Michelle De Leeuw, Tianyu Dai, Marina Moreno‐Mosquera, Andrea Morales, Marc Guiu, Josefina Casas, José Carlos Perales, Roger R. Gomis, Francesc Viñals   +12 more
wiley   +1 more source

Ocrelizumab‐induced colitis: VigiBase disproportionality analysis, case reports and literature review

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2162-2170, July 2026.
Aims Ocrelizumab is a humanized anti‐CD20 monoclonal antibody used in multiple sclerosis. Since its commercialization, several cases of ocrelizumab‐induced colitis have been reported in the scientific literature. Methods To explore the potential association of ocrelizumab with colitis as an adverse drug reaction (ADR), we conducted a descriptive and ...
Audrey Fresse, Christophe Hommel, Nadine Petitpain, Philippe Kerschen   +3 more
wiley   +1 more source

Mechanochemical Hydrodeoxygenations

European Journal of Organic Chemistry, Volume 29, Issue 22, 9 June 2026.
A silver‐catalyzed mechanochemical hydrodeoxygenation with triethylsilane as reductant allows to convert ketones to the corresponding methylene derivatives in good yields after a short reaction time. Selected examples show that also alcohols, ethers, and sulfoxides can react. In this work, a mechanochemical hydrodeoxygenation (HDO) was developed. Using
Lena M. Hanek, Carsten Bolm
wiley   +1 more source