Results 141 to 150 of about 12,591 (290)

Patterns of interaction between patients, family members, and health professionals as markers of identity in palliative care. [PDF]

Palliat Support Care
Neto IG.
europepmc   +1 more source

Facing finitude

, 2022
Kathryn Mannix's book entitled “We Need to Talk About Death” is both personally and professionally transformative. The author approaches, through experiences with her patients at the end of life, the patterns and the unique way each individual experiences finitude; in addition, she discusses the importance of talking about immortality and the human ...
openaire   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Rituais de despedida católicos e finitude: um olhar fenomenológico existencial [PDF]

Este trabalho trata-se de uma revisão bibliográfica acerca de dois temas intimamente relacionados: Finitude e Religião. Busca como objetivo principal compreender a importância dos rituais de despedida dentro da religião católica partindo do conceito de ...
Rienzo, Amanda Figuerola Di
core  

Possible autonomy: Finitude, vulnerability, and the ethical duty of listening. [PDF]

Palliat Support Care
Geber-Júnior JC.
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

From impact factor to human factor: the rise of humanness in the age of intelligent machines. [PDF]

Npj Ment Health Res
Tsai J.
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

The Ground of the Bearer: Finitude vs. Maintenance [PDF]

The bearer-derivation gap in mechanism-first consciousness theory has begun to attract systematic attention. Recent work proposes finitude as the foundational predicate from which bearerhood follows.
Thomas, Charles S.
core