Results 171 to 180 of about 71,417 (302)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Exploring the concept of a "friendly relationship to death" in geriatric patients. [PDF]

BMC Geriatr
Raboti Z, Rösler A, Lindner R, Gallinat J, Schneider BC.   +4 more
europepmc   +1 more source

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source

Existential Psychobiography: On Death and Dying Across the Life Span. Or How Extraordinary Individuals and Their Environments Deal With the End of Life. [PDF]

Eur J Psychol
Mayer CH, Fouché PJP.
europepmc   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Is concurrent training effective in the symptomatology of menopause, depression, sexual function, and the aging perspective of women during menopause? A randomised clinical trial. [PDF]

Prz Menopauzalny
Scarpel CM, Fausto DY, Bocchi Martins JB, de Azevedo Guimarães AC.   +3 more
europepmc   +1 more source

Recovering the Feminine for a Christian Ethic in Medicine [PDF]

, 1986
Lussier, Mary L.
core   +1 more source

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source

Seeking Something Beyond Themselves: A Concept Analysis of Spiritual Awakening Experiences at the End of Life. [PDF]

Nurs Rep
Monteiro M, Vitorino J, Salvetti MG, Laranjeira C.   +3 more
europepmc   +1 more source

Philosophy, Literature, Death, And Wisdom: On Philip Kitcher\u27s Deaths In Venice [PDF]

, 2016
Eldridge, Richard Thomas
core   +1 more source