Results 231 to 240 of about 155,939 (286)

The ALS‐associated E425K mutation uncouples DNAJC7 from the Hsp70 chaperone cycle

The FEBS Journal, EarlyView.
DNAJC7 is a J‐domain protein that plays a key role in protein quality control by regulating Hsp70 activity and preventing protein aggregation. We find that the ALS‐associated E425K mutation in DNAJC7 disrupts productive interaction and activation of Hsp70, thereby blocking the transfer and refolding of client proteins such as TDP‐43.
Bar Elmaleh, Ofrah Faust, Rina Rosenzweig   +2 more
wiley   +1 more source

Use of Fluorescent Catheters to Prevent Urological Organ Injury in Minimally Invasive Colorectal Surgery: A Retrospective Study. [PDF]

In Vivo
Imaizumi K, Ichikawa N, Yagihashi Y, Yoshida T, Ohno Y, Shibata K, Ishizuka C, Sano S, Taketomi A.   +8 more
europepmc   +1 more source

MiR‐155‐5p promotes endothelial–mesenchymal transition and oxidative stress in diabetic retinopathy

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims MicroRNA (miRNA) has been confirmed to be related to gene expression regulation and disease progression. However, the role of miR‐155‐5p in diabetic retinopathy remains unclear. Materials and Methods The retinal microvascular endothelial cells (RMECs) were treated with high glucose, and then the changes of miR‐155‐5p, endothelial cell ...
Wenwen Dou, Changbo Fu, Lei Jin, Ting Li, Mingxing Li   +4 more
wiley   +1 more source

The mitochondrial genome of the firefly, <i>Pyrocoelia amplissima</i> (Olivier, 1886) (Coleoptera: Lampyridae) and its phylogenetic analysis. [PDF]

Mitochondrial DNA B Resour
Wang M, Wang L, Yi C, Tang J, Chen Q, Wei Z, Guo J, Yang Y, Chen S.   +8 more
europepmc   +1 more source

A signaling pathway mediating abscisic acid‐induced jasmonic acid biosynthesis during strawberry ripening

Journal of Integrative Plant Biology, EarlyView.
During strawberry ripening, abscisic acid signaling activates SnRK2.6, which phosphorylates and degrades the JAZ12 repressor. This releases the MYC2 transcription factor, directly activating jasmonic acid biosynthesis genes. The resulting jasmonic acid accumulation drives aroma production, thereby coupling ripening with scent formation through this ...
Kenan Jia, Baozhen Zeng, Zhengrong Dai, Xiaoming Zhang, Jing Wang, Chuanbao Wu, Chen Feng, Guohua Yan, Kaichun Zhang, Xuwei Duan, Wei Wang   +10 more
wiley   +1 more source

Applications of bioluminescence-mediated photodynamic therapy (BL-PDT) for the treatment of deep-seated tumours. [PDF]

Discov Oncol
Mohlongo M, George BP, Abrahamse H.
europepmc   +1 more source

GeARF5/GeIAA33‐GeSWEET14 module balances the secondary metabolic biosynthesis to increase the yield and quality in Gastrodia elata

Journal of Integrative Plant Biology, EarlyView.
Auxin signaling regulates the formation of vegetative propagation corms in Gastrodia elata by regulating sugar‐acid interconversion, which in turn regulates polysaccharide and starch biosynthesis as well as biosynthesis of the bioactive metabolite gastrodin.
Qun Liu, Zhiqing Wu, Yugang Gao, Yue Xu, Pu Zang, Xinyu Yang, Yan Zhao, Pan Liao, Benoît Boachon, Guoyin Kai   +9 more
wiley   +1 more source

Improvement in the potency of a N¹-methylpseudouridine-modified self-amplifying RNA through mutations in the RNA-dependent RNA polymerase. [PDF]

J Biol Chem
Quintana V, Caillava J, Byk LA, Mondotte JA, Battini L, Tarte P, Samsa MM, Filomatori CV, Alvarez DE.   +8 more
europepmc   +1 more source

N-Sulfated Heparan Sulfate Promotes Reelin Signaling as a Co-receptor. [PDF]

J Am Chem Soc
Pan L, Song X, Su G, Gandy LA, Fang B, Buttaci M, Gibson J, Xia K, Zhang F, Liu J, Wang L, Temple S, Wang C.   +12 more
europepmc   +1 more source

HED-ID: an edge-deployable and explainable intrusion detection system optimized via metaheuristic learning. [PDF]

Sci Rep
Nasir K, Badri SK, Alghazzawi DM, Alghamdi MY, Alkhozae M, Almakky A, Alhazmi RM, Asghar MZ.   +7 more
europepmc   +1 more source