Results 81 to 90 of about 1,470,980 (360)

CEO Characteristics, Firm Policy, and Firm Performance

open access: yesInternational Journal of Business and Society, 2022
This research aims to investigate the effect of CEO characteristics (female gender, education, and age) on the financing policy (interest-bearing debt to total assets), investing policy (capital expenditure), and firm performance (return on assets) when it is controlled by firm size and firm age.
null Rahmat Setiawan, null Lila Gestanti
openaire   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

The Effect of Board Characteristics on Firm Performance in Japan

open access: yesEast Asian Economic Review, 2009
This paper analyzes the effect of similarity among board members on firm performance in Japanese manufacturing firms. The similarity measures regarding age and educational background of individual directors were used to predict firm performance.
Oona Cha , Taehun Jung
doaj   +1 more source

Efficacy of firm size and structure on organizational performance [PDF]

open access: yesЕкономіка та управління АПК
Firm size plays an important role in determining firm’s performance even though it’s not clear whether firm size affect organizational perfor[1]mance. Therefore; an investigation is required to assess the effect firm size and structure will have on firm ...
OLALEKAN OWOTUTU SABITU   +2 more
doaj   +1 more source

The Determinants and Outcomes of Forward-Looking Disclosure Evidence from Companies listed in Indonesia [PDF]

open access: yes, 2017
The aim of the study was to examine the determinants and outcomes of forward-looking disclosure. The determinants of forward-looking disclosure were solvability, profitability, liquidity, firm size, and sector type.
HARTO, Puji, ZHAFARINA, Dilla
core  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

THE EFFECT OF FIRM PERFORMANCE, LEVERAGE, FIRM SIZE, AND FIRM GROWTH ON AGENCY COST OF TRADING COMPANY IN INDONESIA, MALAYSIA, AND THAILAND: RESEARCH PERIOD OF 2009 – 2013

open access: yesJurnal Riset Manajemen Sains Indonesia, 2017
In this study,the author investigate the relationship of firm performance, leverage, firm size, and firm growth on the agency cost. In the company’s life, there are several holders an important role in the company itself.
Hamidah Hamidah   +2 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

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