Results 51 to 60 of about 3,152,534 (307)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Numerical Results for Adaptive (negative norm) Constrained First Order System Least Squares Formulations

, 2020
We perform a follow-up computational study of the recently proposed space–time first order system least squares ( FOSLS ) method subject to constraints referred to as CFOSLS where we now combine it with the new capability we have developed, namely ...
Schafelner, Andreas, Vassilevski, Panayot S.   +1 more
core   +2 more sources

The second Weyl coefficient for a first order system [PDF]

, 2020
Edited in accordance with referee's recommendations + updated ...
Avetisyan, Zhirayr, Sjöstrand, Johannes, Vassiliev, Dmitri   +2 more
openaire   +4 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

An Adaptive Wavelet Method for Semi-Linear First-Order System Least Squares

, 2015
We design an adaptive wavelet scheme for solving first-order system least-squares formulations of second-order elliptic PDEs that converge with the best possible rate in linear complexity. A wavelet Riesz basis is constructed for the space H⃗ 0,ΓN(div;Ω)
Chegini, N., Stevenson, R.
core   +1 more source

First-order optical systems with unimodular eigenvalues [PDF]

Journal of the Optical Society of America A, 2006
It is shown that a lossless first-order optical system whose real symplectic ray transformation matrix can be diagonalized and has only unimodular eigenvalues is similar to a separable fractional Fourier transformer in the sense that the ray transformation matrices of the unimodular system and the separable fractional Fourier transformer are related by
Bastiaans, Martin J., Alieva Krasheninnikova, Tatiana   +1 more
openaire   +3 more sources

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source