Results 41 to 50 of about 991,053 (256)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

First Principles

open access: yes, 1897
In 1862, the British philosopher Herbert Spencer (1820–1903) published this preamble to a planned series of publications on biology, psychology, sociology and morality. In it, he states that religion and science can be reconciled by their shared belief in an Absolute, and that ultimate principles can be discerned in all manifestations of the Absolute ...
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

First-principles investigation of phase stability and elastic properties of Laves phase TaCr2 by ruthenium alloying

open access: yesHigh Temperature Materials and Processes, 2023
Based on the first-principles method of density functional theory, the microscopic mechanism of the effect of addition of alloying element Ru content on the stability and elastic properties of Laves phase TaCr2 was investigated by parameters such as ...
Wei Shishi   +4 more
doaj   +1 more source

First-Principles Assessment: Physicalism and Idealism at First Principles

open access: yes
Abstract: Physicalism and analytic idealism are compared at the level of first principles — not theory maturity, not evidential closure, not institutional success — using five symmetric criteria that both frameworks accept: epistemic direction, brute-fact placement, handling of the hard problem, parsimony of ontological categories, and self-referential
  +10 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

First-principles study on properties of singlr-layer phosphorene with doping copper, silver and gold

open access: yes四川大学学报. 自然科学版, 2020
In this paper, we studied the geometries, stabilities, band structures and densities of states of copper, silver and gold doped phosphonenes. The biggest distortion of geometric structure is the structure of gold doped phosphonene, however, it is the ...
FU Chun-Ping   +4 more
doaj  

DFT predictions of ferromagnetism in the AlC0.0625N0.9375 and AlC0.125N0.875 compounds

open access: yesResults in Physics, 2015
We employed density functional theory (DFT) in order to study the structural, electronic, and magnetic properties of pure AlN and C-atom-doped AlN compounds. The calculations were carried out using the method based on pseudopotential, employed exactly as
J.F. Murillo G   +2 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Achieving High-Performance Solution-Processed Thin-Film Transistors by Doping Strong Reducibility Element Into Indium-Zinc-Oxide

open access: yesIEEE Journal of the Electron Devices Society, 2023
Adding an appropriate amount of suitable elements is an effective way to suppress In-Zn-O (IZO) carriers. The influence of different doping concentration Ca incorporation on In-Zn-O oxide-based thin film transistors (Ca-IZO TFTs) was investigated ...
Jifang Cao   +4 more
doaj   +1 more source

Home - About - Disclaimer - Privacy