Results 81 to 90 of about 26,513 (266)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Geometric interpretation of integrals

open access: yesLietuvos Matematikos Rinkinys, 2010
There are considered the geometric interpretation of curvilinear intels of first and second type. The integrals first type are interpretated like area of cilindric figure, the integrals of second type – like area of projection of the same cilindric ...
Gintaras Puriuškis
doaj   +1 more source

Hyperbolicity, transversality and analytic first integrals

open access: yesJournal of Differential Equations, 2004
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

Task-First or Context-First? Tool Integration Revisited [PDF]

open access: yes2009 IEEE/ACM International Conference on Automated Software Engineering, 2009
If software engineering tools are not "properly integrated", they can reduce engineers' productivity. Associating and retrieving information scattered across the tools become unsystematic and inefficient. Our work provides empirical evidence on what is a "poor" and a "proper" tool integration, focusing on practitioners' perspectives.
openaire   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

First Integrals of the May–Leonard Asymmetric System

open access: yesMathematics, 2019
For the May–Leonard asymmetric system, which is a quadratic system of the Lotka–Volterra type depending on six parameters, we first look for subfamilies admitting invariant algebraic surfaces of degree two.
Valery Antonov   +3 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

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