Results 61 to 70 of about 14,782,076 (302)

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source

TRAF6 Lactylation in Glycolytic Macrophages Drives NF‐κB Signaling and M1 Polarization During Orthodontic Tooth Movement

Advanced Science, EarlyView.
Schematic diagram showing compressive stress triggers glycolytic reprogramming and lactate accumulation in macrophages. Lactate mediates TRAF6 lactylation at K171/K180 dual sites, which enhances its K63‐linked ubiquitination to activate the NF‑κB pathway and promote M1 polarization. This cascade drives orthodontic tooth movement (OTM) and alveolar bone
Xinyi He, Guodong Zhao, Yun Hu, Wenya Bai, Hao Tan, Shuai Yuan, Sihan Yang, Ye Zhu, Xiaohui Xu, Leilei Zheng   +9 more
wiley   +1 more source

Effects of Isolation of Calves on Growth, Behavior, and First Lactation Milk Yield of Holstein Cows

Journal of Dairy Science, 1992
Holstein (n = 323) calves in the herds of four experiment stations were reared individually (control) or in isolation to 70 d of age to determine whether isolation affected growth, behavior, and first lactation yield. Treatment differences were not observed for average daily gain for BW at d 28, 56 or 70.
C W, Arave, J L, Albright, D V, Armstrong, W W, Foster, L L, Larson   +4 more
openaire   +2 more sources

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source

Genetic studies on various production and reproduction traits of Sahiwal and crossbred cattle (HFxJerseyxSahiwal) of an organised farm

Veterinary World, 2010
The present investigation was undertaken on data of 30 Sahiwal cattle and 30 crossbred cattle (HF × Jersey × Sahiwal) from Instructional Dairy Farm (IDF), G.B. Pant University of Agriculture & Technology, Pantnagar, Uttarakhand.
Anjan Dandapat, Dipak Banerjee, Dibyendu Chakraborty   +2 more
doaj  

Fertility and milking traits of Sanska goat in first three lactations [PDF]

Agroznanje, 2013
The research has been conducted on Sanska goat breed in the first, second and third lactation. Milk yield control was conducted after weaning period in the intervals of 30 days.
Mekić Cvijan, Perišić Predrag, Novaković Zorica, Petrović Milan P.   +3 more
doaj   +1 more source

First Lactation Milk Yield Predicted by the Heifer’s Growth Curve Derivatives

Dairy
Replacement heifers are regularly weighed to assess their health. These data also predict the milk yield in their first lactation (L). The first derivative of the growth curve represents the weight change rate at a given time. It is interesting to use the higher-order derivatives of one biological process, such as growth, to predict the outcome of ...
Aurelio Guevara-Escobar, Mónica Cervantes-Jiménez, Vicente Lemus-Ramírez, José Guadalupe García-Muñiz, Adolfo Kunio Yabuta Osorio   +4 more
openaire   +2 more sources

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

ENVIRONMENTAL FACTORS AFFECTING MILK YIELD AND LACTATION LENGTH IN SAHIWAL CATTLE [PDF]

Pakistan Veterinary Journal, 2004
Weekly milk yield records on 661 Sahiwal cows calving during 1990-2000 at the Livestock Experiment Station Bahadurnagar, Okara were used to study how milk yield and lactation length were affected by different environmental factors.
I.R. Bajwa, M. S. Khan, M. A. Khan1 and K. Z. Gondal2
doaj