Results 71 to 80 of about 14,782,076 (302)

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

open access: yesAdvanced Science, EarlyView.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon   +27 more
wiley   +1 more source

EFFECTS OF MONTH AND YEAR OF CALVING ON 305-DAY MILK YIELD IN HOLSTEIN-FRIESIAN CATTLE IN NWFP, PAKISTAN

open access: yesPakistan Veterinary Journal, 2002
Data on production performance of 90 imported Dutch Holstein-Friesian cattle and their 127 Pakistani- born progeny from 1982 to 1991 were analyzed. The mean first lactation 305-day milk yield for imported and Pakistani-born cows was 3196.7 ± 66.36 and ...
Asad Ullah Hyder and Samee Ullah1
doaj  

Relationship between average daily gain of heifers at various stages of rearing and milk production in the first and second lactation

open access: yesJournal of Dairy Science
: The study aimed to determine whether ADG of Holstein heifers at various stages of rearing affects first and second lactation performance. Data on BW of heifers were obtained from 3 independent dairy operators (operators A, B and C) and used to ...
A. Garus-Piętak   +5 more
doaj   +1 more source

REGRESSION TREE ANALYSIS OF FACTORS AFFECTING FIRST LACTATION MILK YIELD OF DAIRY CATTLE

open access: yesApplied Ecology and Environmental Research, 2019
The objective of this study was to examine the effects of management and environmental effects on first lactation milk yield by means of regression tree method. Regression tree method is useful to determine the effects of several factors on specified depended variables.
Mikail, Nazire, Bakır, Galip
openaire   +2 more sources

Response to somatic cell count-based selection for mastitis resistance in a divergent selection experiment in sheep [PDF]

open access: yes, 2009
A divergent selection experiment in sheep was implemented to study the consequences of log-transformed somatic cell score (SCS)-based selection on resistance to natural intramammary infections.
Aurel, Marie-Rose   +8 more
core   +1 more source

UFL1‐Mediated UFMylation of ENO1 Restrains Aerobic Glycolysis and Colorectal Cancer Progression

open access: yesAdvanced Science, EarlyView.
UFMylation restrains aerobic glycolysis and colorectal cancer progression by modifying the glycolytic enzyme ENO1. Pharmacological enhancement of the UFL1–ENO1 interaction by the FDA‐approved antibiotic torezolid promotes ENO1 UFMylation, suppresses tumor metabolism, and sensitizes colorectal cancer to chemotherapy, revealing an actionable metabolic ...
Xiuqing Ma   +14 more
wiley   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

open access: yesAdvanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni   +17 more
wiley   +1 more source

Genomic insights: Disentangling milk yield and reproduction performance in first-lactation German Holsteins

open access: yesJournal of Dairy Science
This study offers insight into the genetic complexity of the interaction between production and reproduction in German dairy cows. The phenotypes and genotypes of 32,352 primiparous German Holstein cows were available for investigation, and datasets (DS) of similar size were generated according to their milk yield. Five distinct DS, each including more
Leopold Schwarz   +4 more
openaire   +4 more sources

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin   +17 more
wiley   +1 more source

Effects of calf sex, breed and parity on the lactation performance of dairy cows in Trinidad and Tobago

open access: yesDiscover Agriculture
Dairy farming is important for food and nutrition security and livelihood protection in most tropical countries. However, productivity of dairy cows is affected by many factors and is usually low on smallholder farms in tropical environments.
Erica Auguste   +2 more
doaj   +1 more source

Home - About - Disclaimer - Privacy