Results 91 to 100 of about 26,268,555 (308)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Optimal first‐line treatment for advanced thymic carcinoma

Thoracic Cancer, 2019
Background Thymic carcinomas (TCs) are rare aggressive tumors with no standard first‐line treatment. This study was conducted to determine the optimal chemotherapy regimen for advanced TC. Methods This retrospective study included 67 patients treated for
Xue Yang, Minglei Zhuo, Anhui Shi, Shengnan Yang, Ziping Wang, Meina Wu, Tongtong An, Yuyan Wang, Jianjie Li, Jia Zhong, Hanxiao Chen, Bo Jia, Zhi Dong, Jun Zhao   +13 more
doaj   +1 more source

First-line treatment for hypertension [PDF]

European Heart Journal, 2002
P R, Jackson, L E, Ramsay
openaire   +2 more sources

Toxicity associated with stavudine dose reduction from 40 to 30 mg in first-line antiretroviral therapy. [PDF]

, 2011
To compare the incidence and timing of toxicity associated with the use of a reduced dose of stavudine from 40 to 30 mg in first-line antiretroviral therapy (ART) for HIV treatment and to investigate associated risk ...
Etard, JF, Pinoges Loretxu, Pujades-Rodriguez, M., Etard Jean-François, Pujades-Rodríguez, M, Jean-François Etard, Pinoges, Loretxu, Szumilin Elisabeth, Dantony, E, AIDS Working Group of Médecins Sans Frontières, Szumilin, E, Etard, Jean-François, Szumilin, Elisabeth, Ecochard, R, René Ecochard, Dantony Emmanuelle, Pinoges, L., Dantony, Emmanuelle, Ecochard René, Carrillo-Casas, Esther, Pinoges, L, Ecochard, René, Elisabeth Szumilin, Carrillo-Casas, E, Carrillo-Casas Esther, Esther Carrillo-Casas, Emmanuelle Dantony, Pujades-Rodríguez Mar, Etard, J.F., Carillo-Casa, E., Loretxu Pinoges, Szumilin, E., Mar Pujades-Rodríguez, Carrillo-Casas, E., Pujades-Rodríguez, Mar, Ecochard, R., Dantony, E.   +36 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

A Multicenter Retrospective Study: Impact of First-Line Treatment Strategies on second-Line Efficacy and Safety of Regorafenib with or Without PD-1 Inhibitors in Unresectable Hepatocellular Carcinoma

Journal of Hepatocellular Carcinoma
Weihong Ma,1,2,* Yinyin Li,1,* Yinying Lu,1,2 Zhipeng Liang,3 Hongli Yu,1,2 Jie Han,1,2 Jiaqi Liu,1,2 Wenjing Wang,1,2 Caiyun Peng,1 Jiamin Cheng1 1Senior Department of Hepatology, The 5th Medical Center of the PLA General Hospital ...
Ma W, Li Y, Lu Y, Liang Z, Yu H, Han J, Liu J, Wang W, Peng C, Cheng J   +9 more
doaj  

Inhaled Steroids: First Line Treatment of Adult Asthma

Canadian Respiratory Journal, 1995
Corticosteroids are the most potent inhaled anti-inflammatory drugs for asthma treatment. This paper reviews the clinical evidence supporting the early use of inhaled steroids in asthma as a first line treatment.
André Cartier
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Biliary tract cancer: current challenges and future prospects

Cancer Management and Research, 2018
Michele Ghidini,1 Claudio Pizzo,1 Andrea Botticelli,2 Jens Claus Hahne,3 Rodolfo Passalacqua,1 Gianluca Tomasello,1 Fausto Petrelli4 1Department of Oncology, Azienda Socio Sanitaria Territoriale of Cremona, Cremona, Italy; 2Department of Clinical and ...
Ghidini M, Pizzo C, Botticelli A, Hahne JC, Passalacqua R, Tomasello G, Petrelli F   +6 more
doaj  

First-line antiretroviral treatment failure and associated factors in HIV patients at University of Gondar Teaching Hospital, Gondar, Northwest Ethiopia

, 2016
Mohammed Biset Ayalew,1 Dawit Kumilachew,2 Assefa Belay,3 Samson Getu,4 Derso Teju,4 Desalegn Endale,4 Yemisirach Tsegaye,4 Zebiba Wale4 1Department of Clinical Pharmacy, 2Department of Pharmaceutics, 3Department of Pharmacology, 4School of Pharmacy ...
Wale Z, Belay A, Tsegaye Y, Teju D, Kumilachew D, Ayalew MB, Getu S, Endale D   +7 more
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