Results 71 to 80 of about 26,268,555 (308)

First Line CombinAtion Therapy in the Treatment of Stage II and III Hypertension (FLASH). [PDF]

, 2020
Background: Lowering blood pressure (BP) leads to reduced risk of stroke, myocardial infarction, and cardiovascular mortality. Single-pill combination therapies may deliver better BP control than increasing the dose of monotherapies or using more drugs ...
Burnier, Michel, Spirk, D., Noll, S., Noll, Sarah, Sudano, I., Rimoldi, Stefano, Noll, Georg, Sudano, Isabella, Burnier, M., Spirk, David, Noll, G., Rimoldi, S., Noll G, Sudano I, Spirk D, Rimoldi S, Burnier M, Noll S   +17 more
core   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Percent of individuals starting partially inactive second-line treatment due to acquired drug resistance during first-line treatment.

, 2012
Percent of individuals starting partially inactive second-line treatment due to acquired drug resistance during first-line treatment.
Valentina Cambiano (146513), Deenan Pillay (7888), Silvia Bertagnolio (57174), Michael R. Jordan (146520), Andrew N. Phillips (146556), Alec Miners (146534), Jens Lundgren (146550), Viktor von Wyl (146506)   +7 more
core   +1 more source

Clinical Outcomes with First-line Endocrine Therapy or Chemotherapy in Postmenopausal HR+/HER2- Metastatic Breast Cancer [PDF]

, 2015
Objective To describe patient profiles and clinical outcomes associated with first-line endocrine monotherapy (ET) and chemotherapy (CT) for postmenopausal HR+/HER2– metastatic breast cancer (mBC) patients. Methods This is a retrospective chart review of
Yanni Hao, Alexander R. Macalalad, Eric Q. Wu, Yan Song, James E. Signorovitch, Peggy L. Lin   +5 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Comparative effectiveness of different chemotherapies given to Nodular Lymphocyte Predominant Hodgkin Lymphoma patients: A retrospective study from Lahore, Pakistan

Cancer Treatment and Research Communications
Nodular Lymphocyte Predominant Hodgkin Lymphoma (NLPHL) is a rare type of Hodgkin lymphoma. This retrospective study aims to find most efficient chemotherapy that gives high rates of Progression Free Survival (PFS) and overall survival (OS).
Namra Jabeen, Nazia Kanwal, Haroon Ibrahim, Aamir Amin   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Optimal first-line treatment in ovarian cancer

Annals of Oncology, 2012
Treatment of ovarian cancer remains challenging despite the high complete response rate seen after maximal surgical debulking surgery and platinum-combination chemotherapy. as most patients will relapse and eventually succumb to ovarian cancer, new strategies are urgently required to improve survival.
F A, Raja, N, Chopra, J A, Ledermann
openaire   +2 more sources

Prolonged survival of patients receiving trastuzumab beyond disease progression for HER2 overexpressing metastatic breast cancer (MBC) [PDF]

, 2005
Background: The aim of this retrospective analysis was to evaluate the impact of trastuzumab-based regimens on the survival of patients with HER2-overexpressing metastatic breast cancer (MBC).
Heinrich, B., Stemmler, H. J., Kahlert, S., Heinemann, Volker, Siekiera, W., Untch, M.   +5 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source