Results 81 to 90 of about 26,268,555 (308)

First-line treatment of chronic myeloid leukemia with nilotinib: critical evaluation

Journal of Blood Medicine, 2012
Pier Paolo Piccaluga,* Stefania Paolini,* Clara Bertuzzi, Antonio De Leo, Gianantonio RostiHematopathology and Hematology Sections, Department of Hematology and Oncological Sciences, "L and A Seràgnoli", S Orsola-Malpighi ...
Piccaluga PP, Paolini S, Bertuzzi C, De Leo A, Rosti G   +4 more
doaj  

Waterfall plot of treatment-free interval following first-line therapy.

, 2020
Waterfall plot of treatment-free interval following first-line therapy.
Toby A. Eyre (8479401), Grant Vallance (6078815), Susan McLain-Smith (8479398), Sally Moore (6078818), Faye A. Sharpley (8479395), Jaimal Kothari (6078821), Karthik Ramasamy (795392), Faouzi Djebbari (6004379)   +7 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Case report: Transformative potential of trastuzumab deruxtecan in the first line treatment for advanced HER2-mutated lung adenocarcinoma: a case report and clinical insights

Frontiers in Pharmacology
The treatment of non-small cell lung cancer (NSCLC), particularly lung adenocarcinoma (LUAD), represents a significant oncological challenge due to its aggressive behavior, high metastatic potential and poor prognosis.
Guanbin Huang, Tongtong Xia, Dongxiao Yang, Muwen Lin, Yiping Luo, Yuchan Li, Hualin Chen   +6 more
doaj   +1 more source

Adaptive guidelines to inform first-line treatment recommendations for gonorrhea.

, 2020
Adaptive guidelines to inform first-line treatment recommendations for gonorrhea.
Reza Yaesoubi (207900), Joshua A. Salomon (8668311), Harrell Chesson (8668308), Thomas L. Gift (8668305), Katherine Hsu (8668302), Yonatan H. Grad (3123549), Ted Cohen (118302)   +6 more
core   +1 more source

The efficacy of antimalarial monotherapies, sulphadoxine-pyrimethamine and amodiaquine in East Africa: implications for sub-regional policy. [PDF]

, 2003
Between 1998 and 2001, Kenya, Uganda, Tanzania, Zanzibar, Rwanda and Burundi changed antimalarial drug policy, in the face of widespread chloroquine resistance.
East African Network for Monitoring Antimalarial Treatment (EANMAT), East African Network for Monitoring Antimalarial Treatment (EANM   +1 more
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Selecting first-line immunotherapy in advanced melanoma: Current evidence on efficacy across diverse patient populations

EJC Skin Cancer
Immunotherapy has dramatically changed the outcome for patients with advanced melanoma, with significant improvements in overall survival and potential cure for some.
Sophia Kreft, Tommaso Bosetti, Rebecca Lee, Paul Lorigan   +3 more
doaj   +1 more source

Urinary Incontinence: Diagnostic Evaluation and First-line Treatment

Southeastern European Medical Journal, 2020
Urinary incontinence is defined as involuntary leakage of any amount of urine that negatively affects the individual's hygienic and social status. It is an important public health problem because it has a high prevalence and incidence.
Ivan Radoja, Dunja Degmečić
doaj   +1 more source

First-line treatment of advanced ALK-positive non-small-cell lung cancer

, 2015
Shipra Gandhi,1 Hongbin Chen,2 Yujie Zhao,2 Grace K Dy2 1Department of Internal Medicine, State University of New York, 2Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA Abstract: Non-small-cell lung cancer (NSCLC) is one of the ...
Gandhi S, Dy GK, Chen H, Zhao Y
core