Results 51 to 60 of about 370,468 (305)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Financial Policies Supporting Acceleration of Sustainable Economic and Fiscal Growth in Indonesia

Ijtimā'iyya, 2020
This paper explores the fiscal policy of a country, as well as the policies that influence the economic growth of a country, since the course of government decision-making would be decided by fiscal policy and government expenditure.
Fikry Ramadhan Suhendar, Nurlailiyah Aidatus Sholihah   +1 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

La administración de la bula de la Santa Cruzada en Nueva España (1547-1659)

Historia Mexicana El Colegio de México, 2013
La bula de la Santa Cruzada constituyó uno de los ingresos más originales de la Real Hacienda. Se trataba de las limosnas que aportaban los fieles para obtener indulgencias, exenciones de ayunos y otros privilegios espirituales y, por tanto, de una renta
María del Pilar Martínez López-Cano
doaj  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Estrategia lúdica para desarrollar aprendizaje significativo en la asignatura de matemática

Gade: Revista Científica
La enseñanza de las matemáticas en el décimo año enfrenta desafíos significativos en la creación de un aprendizaje significativo. El objetivo de este estudio es evaluar la efectividad de diferentes estrategias lúdicas aplicadas en la educación ...
Carmen Elizabeth Yanchapaxi Molina, Fabian Filberto Fuentes Quisaguano, Luis Manolo Córdova Chiriboga, Dayana Catherine Chicaiza Morocho, Luis Marcelo Muñoz Carrera   +4 more
doaj   +1 more source

THE SELECTION OF OBJECTIVES BY FISCAL POLITICS [PDF]

Annals of the University of Oradea: Economic Science, 2010
The multitude of fiscal politics` objectives supposes a rational and a well-informed selection of them. Fiscal politics handle specific instruments and levers , producing effects which are hard enough to be quantified and reactions, which most of the ...
Morar Ioan Dan
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

O regime de transparência fiscal nas sociedades de gestão de imóveis [artigo de imprensa]

, 2023
O Código do IRC determina a sujeição ao regime de transparência fiscal, entre outras, às sociedades de simples administração de bens, pelo que se pretende aqui analisar as especificidades da sua aplicação.
Aldeia, Susana
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source