Results 61 to 70 of about 370,835 (304)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Policy lags and exchange rate dynamics in Nigeria: Any evidence?

open access: yesJurnal Ekonomi Pembangunan, 2020
The study investigates policy lags and exchange rate dynamics in Nigeria. The downswing in the Nigerian economy attributed to recurring exchange rate fluctuations justifies this empirical investigation.
Ayinde Taofeek Olusola
doaj  

Fiscal Contitutionalism

open access: yes, 2006
The object of this paper is to provide a general overview of that area of intellectual activity characterized by the application of so-called “constitutional economics” to fiscal phenomena. We call this area “fiscal constitutionalism”. In modern times, it has been associated most notably with the work of James Buchanan and those operating in his ...
Geoffrey Brennan, EUSEPI, Giuseppe
openaire   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

A note on inflation, unemployment and economic growth

open access: yesPSL Quarterly Review, 2014
Although even before the end of World War II the world was preparing itself to fight a relapse into stagnation, the harrowing role inflation was to have as a constant in the post-war economic scene was scarcely perceived.
G. MAGNIFICO
doaj   +1 more source

FISCAL RULES IN THE LIGHT OF THE FISCAL CRISIS

open access: yesEkonomia i Prawo, 2012
The article presents the essence and the meaning of the fiscal rules of the budgetary policy with particular emphasis on the period of financial crisis since 2008. The author presets the fiscal rules (criteria) in the European Union and national solutions.
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

ANCHORING FISCAL EXPECTATIONS [PDF]

open access: yes
In this lecture, I argue that there are remarkable parallels between how monetary and fiscal policies operate on the macro economy and that these parallels are sufficient to lead us to think about transforming fiscal policy and fiscal institutions as ...
Eric M. Leeper
core   +3 more sources

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

NOVEDOSA TENDENCIA JURISPRUDENCIAL COLOMBIANA SOBRE RESPONSABILIDAD DEL ESTADO POR ACTOS TERRORISTAS

open access: yesProlegómenos, 2010
La Jurisprudencia del Consejo de Estado comienza a mostrar una tendencia novedosa y muy criticada, en materia de declaratoria de responsabilidad del Estado por actos de terrorismo.
Yolanda Margaux Guerra
doaj  

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