Results 81 to 90 of about 370,835 (304)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
As iniciativas tributárias europeias e a agenda fiscal verde [artigo de imprensa] [PDF]
Ao nível fiscal, a UE tem vindo a introduzir um conjunto de iniciativas tributárias que promovem os objetivos da agenda fiscal verde, ou seja, contribuindo para os objetivos climáticos da UE de reduzir as emissões de gases com efeito de estufa em pelo ...
Aldeia, Susana
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Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
O Planeamento Fiscal Abusivo [PDF]
, 2018 O presente trabalho versa sobre o tema de planeamento fiscal, com foco no planeamento fiscal exercido de forma abusiva ou agressiva. Hoje é possível através do aproveitamento de “brechas na lei” fazer-se a chamada poupança fiscal. Esse planeamento fiscal
Nascimento, Hernani
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Measuring fiscal structural reform intensity: The case of Armenia [PDF]
Public and Municipal FinanceType of the article: Research Article AbstractFiscal structural reforms play a decisive role in strengthening macroeconomic stability, enhancing public sector efficiency, and improving institutional resilience in transition economies. Armenia represents
Tatul M. Mkrtchyan, Narine Petrosyan
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Fiscal Transparency and Procyclical Fiscal Policy [PDF]
This paper examines why fiscal policy is procyclical in developing as well as developed countries. We introduce the concept of fiscal transparency into a model of retrospective voting, in which a political agency problem between voters and politicians ...
Lasse Holbøll Westh Nielsen +1 more
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CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Jurnal Ekonomi Pembangunan: Kajian Masalah Ekonomi dan Pembangunan, 2015 This study attempts to analyze the role of fiscal capacity in poverty alleviation in Yogyakarta for the period of 2006-2013. For this purpose, this study uses panel data approach to estimate the empirical model involving four regencies and a city.
Jaka Sriyana
doaj