Results 61 to 70 of about 2,341,935 (307)

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

La insoportable carga de Leviathan. Deuda pública y alivio fiscal de los vasallos en el reinado de Carlos II = Leviathan’s Unbearable Burden. Public Debt and Fiscal Relief of the Vassals in the Reign of Carlos II

Espacio, Tiempo y Forma. Serie IV, Historia Moderna, 2020
La decadencia del imperio español durante el siglo XVII ha estado vinculada a un creciente descontrol fiscal y financiero de la hacienda estatal. No obstante, venimos asistiendo a una profunda renovación de esta imagen pesimista y finalista.
Rafael Torres Sánchez
doaj   +1 more source

Fiscal Reality and the American Way of War

Military Strategy Magazine, 2012
What is the strategic meaning of America’s military drawdown? In this article, Macgregor explains the rationale for a reduced footprint overseas and the resulting demand for “high lethality/low density forces” in American military power.
openaire   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Lebanon’s Fiscal Crisis and Economic Reconstruction after War: the case of a bridge too far? [PDF]

Since the onset of the Civil War in 1975 Lebanon has experienced burgeoning fiscal deficits and an unsustainable public debt overhang. Much of this arose from the loss of revenues during the period of the Civil War 1975-90 and attempts to maintain basic ...
Saleh, Ali Salman, Harvie, Charles
core  

HOLLOW VICTORY? BRITAIN’S PUBLIC DEBT AND THE SEVEN YEARS’ WAR

Essays in Economic and Business History, 2011
This article addresses the implications of the cost of warfare and the debt burdens that typically arise from conflicts. It examines how much Britain’s public debt rose during and after the Seven Years’ War and the implications of this growth.
Jari Eloranta, Jeremy Land
doaj   +2 more sources

BUDGET AND TAX REGULATION OF THE DEVELOPMENT OF THE MILITARY-INDUSTRIAL COMPLEX OF UKRAINE IN THE CONTEXT OF ENSURING NATIONAL SECURITY

Фінансово-кредитна діяльність: проблеми теорії та практики
The significance of this study stems from the decisive role of fiscal and tax regulation in supporting the modernization of Ukraine’s military-industrial complex (MIC).
Тетяна Косова, Станіслав Чередніченко, Юлія Керпатенко, Євген Тренкін, Ярослав Якубов   +4 more
doaj   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Sustainability of Swiss Fiscal Policy [PDF]

We examine whether Swiss federal fiscal policy was sustainable over the period from 1900 to 2002. We perform unit root and cointegration tests for federal revenues and expenditures, taking into account a structural shift in the budgetary process related ...
Gebhard Kirchgässner, Silika Prohl
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