Results 131 to 140 of about 3,056,976 (349)

Brewers’ Yeast (Saccharomyces cerevisiae) Purified Functional Feed Additives Mitigate Soybean Meal-Induced Enteritis in Atlantic Salmon (Salmo salar) Parr

open access: yesAquaculture Nutrition
Soybean meal (SBM) is commonly used in aquafeeds due to its wide availability, reasonable protein content, and cost-effectiveness. However, high SBM inclusion levels in the diets of carnivorous fish, such as Atlantic salmon (Salmo salar), can cause ...
Taofik A. Momoh   +7 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Cholesterol Modifies Nutritional Values and Flavor Qualities in Female Swimming Crab (Portunus trituberculatus)

open access: yesAquaculture Nutrition
The quality of crustacean aquatic products is affected by feed. Cholesterol (CHO), an essential element for crustacean growth, has been widely supplemented in diet, but its food quality regulation remains unclear.
Tingting Zhu   +6 more
doaj   +1 more source

Landscape Evolution as a Diversification Driver in Freshwater Fishes [PDF]

open access: gold, 2022
Pedro Val   +4 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Flavor Formation in Dry-Cured Fish: Regulation by Microbial Communities and Endogenous Enzymes [PDF]

open access: gold, 2023
Jiayue Liu   +5 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Postfledging survival of the Worthington's Marsh Wren (Cistothorus palustris griseus)

open access: yesAvian Conservation and Ecology, 2019
The postfledging period of a passerine bird's life is increasingly recognized as an understudied component of songbird conservation, because the habitat needs of fledglings can differ from nesting adults and survivorship during this period can ...
W. Andrew Cox   +2 more
doaj  

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