Results 151 to 160 of about 1,198,477 (317)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Review report on Columbia River and tributaries. Appendix P : Fish and wildlife in Columbia River Basin [PDF]

1. Fish and wildlife are important resources of the Columbia River basin and of the Pacific Northwest. The public interest in the conservation of these resources and necessity for effectual planning in connection with water-use development projects are ...
United States. Army. Corps of Engineers, U.S. Fish and Wildlife Service. Division of Ecological Services. Portland Field Office   +1 more
core  

Multimodal treatment for liver abscess caused by fish bone migration: a case report. [PDF]

J Surg Case Rep
Sonoda A, Ohmoto K, Togashi A, Naoe H, Okino T, Ohara C.   +5 more
europepmc   +1 more source

One Fish or Two Fish, Red Fish or Blue Fish [PDF]

Conservation Biology, 2012
openaire   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Fish Commission research briefs. Vol. 5, no. 1 [PDF]

These short reports are intended to inform the public, industry, and other interested parties of the current studies of the Commission's staff and of the basis for conservation measures.
Oregon. Fish Commission
core  

Impacts of Replacing Fish Meal With Duck By-Product Meal in Diets on Growth Performance, Feed Utilization, and Economic Efficiency of Olive Flounder (<i>Paralichthys olivaceus</i>). [PDF]

Aquac Nutr
Shin SW, Cho SH.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Escape port requirements on commercial crab pots [PDF]

This is an Oregon Dept. of Fish and Wildlife exhibit for a meeting of the Oregon State Fish and Wildlife Commission. "Problem: Oregon crab fishermen are concerned that 4-3/8" escape ports in crab pots allow too many legal male crabs to escape.
Oregon. Department of Fish and Wildlife. Fish Division
core   +1 more source

Laparoscopic Removal of a Fish Bone Causing an Abdominal Wall Abscess Using Laparoscopic Ultrasonography: A Case Report. [PDF]

Surg Case Rep
Uezu I, Takamiyagi Y, Chibana T, Kato K, Chinen Y, Nagahama M, Tomori H.   +6 more
europepmc   +1 more source