Results 51 to 60 of about 830,683 (322)

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

The Relationship between Spatial Ability and the Conservation of Matter in Middle School

Education Sciences, 2020
Research has shown that spatial ability plays a key role in understanding STEM (Science, Technology, Engineering, and Mathematics) content, including chemistry.
Merryn Cole, Jennifer Wilhelm, Briana Marie-McKnight Vaught, Corinne Fish, Hailey Fish   +4 more
doaj   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Cost-Effective Approach to Reducing Collisions with Elk by Fencing Between Existing Highway Structures

Human-Wildlife Interactions, 2017
Collisions with large ungulates cause serious human and animal injuries and significant property damage. Therefore, wildlife crossing structures are increasingly included in new road construction to reduce wildlife–vehicle collisions, while still ...
Jeffrey W. Gagnon, Chad D. Loberger, Scott C. Sprague, Kari S. Ogren, Susan L. Boe, Raymond E. Schweinsburg   +5 more
doaj   +1 more source

Feeding control and water quality monitoring in aquaculture systems: Opportunities and challenges [PDF]

arXiv, 2023
Aquaculture systems can benefit from the recent development of advanced control strategies to reduce operating costs and fish loss and increase growth production efficiency, resulting in fish welfare and health. Monitoring the water quality and controlling feeding are fundamental elements of balancing fish productivity and shaping the fish growth ...
arxiv  

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

Dual Mode Logic—Design for Energy Efficiency and High Performance

IEEE Access, 2013
The recently proposed dual mode logic (DML) gates family enables a very high level of energy-delay optimization flexibility at the gate level. In this paper, this flexibility is utilized to improve energy efficiency and performance of combinatorial ...
Itamar Levi, Alexander Fish
doaj   +1 more source

FishMOT: A Simple and Effective Method for Fish Tracking Based on IoU Matching [PDF]

arXiv, 2023
Fish tracking plays a vital role in understanding fish behavior and ecology. However, existing tracking methods face challenges in accuracy and robustness dues to morphological change of fish, occlusion and complex environment. This paper proposes FishMOT(Multiple Object Tracking for Fish), a novel fish tracking approach combining object detection and ...
arxiv  

A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini, Ezgi Oner, Mark P. Ward, Sinead Hurley, Brian David Henderson, Faye Lewis, Stephen P. Finn, Gerard J. Fitzmaurice, John J. O'Leary, Sharon O'Toole, Lorraine O'Driscoll, Kathy Gately   +11 more
wiley   +1 more source