Results 81 to 90 of about 2,729,373 (300)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Assessing detection of New Zealand mudsnails at low densities in Arizona streams [PDF]
Aquatic InvasionsThe New Zealand mudsnail (NZMS) is a small-bodied gastropod that has successfully invaded waters across multiple continents. This species has the ability to reach extremely high densities in streams and exclude other aquatic macroinvertebrates which ...
Crosby K. Hedden +4 more
doaj +3 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The Fish Funnel: A Trawl Modification to Reduce Fish Escapement [PDF]
, 1989 In the Gulf of Mexico there is a need to assess the potential of underutilized fish resource stocks before a commercial fishery develops. Standard sampling trawls used in the Gulf are ineffective for sampling the resource, so larger, high opening, bottom
Taylor, Charles W., Workman, Ian K.
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The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Braid variants and their applications [PDF]
In Part I we develop the theory of arcbraids and arclinks, which are generalisations of the usual notions of braids and links; an alternative name for arclinks is irrational tangles. A cubical set without degeneracies is called a D-set.
Fish, Andrew
core
Evaluation of the contribution of fisheries and aquaculture to food security in developing countries [PDF]
, 2005 Fish contain important nutrients such as essential fatty acids, iron, zinc, calcium, vitamin A and vitamin C. Production of freshwater fish depends on the strategic application of various management techniques.
Akpaniteaku, R.C. +2 more
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Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Stanowisko tekstualne nie istnieje
Er(r)go, 2006 Leszek Drong's Polish translation of Stanley Fish's essay.
Stanley Fish
doaj
South African Journal of Business Management, 2007 The purpose of the Medical Schemes Act, No. 131 of 1998 was inter alia to ‘promote non discriminatory access to privately funded health care’. A number of reforms were proposed as steps on a path to Social Health Insurance (SHI) with the ultimate goal of
T. Fish, S. Ramjee
doaj +1 more source