Results 101 to 110 of about 779,549 (316)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Sea fish culture in Britain [PDF]

, 1966
J. E. Shelbourne, Colin E. Nash
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Role of fish in enhancing ricefield ecology and in integrated pest management: summary report [PDF]

Summary report of the Third Asian Regional Rice-Fish Farming Research and Development Workshop, Indonesia, 1993. Includes sessions on ricefield ecology and fish; integrated pest management (IPM); research methodology; and IPM adoption.Rice-fish ...
dela Cruz, C.R. (ed.)
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Review of aquaculture and fish consumption in Bangladesh [PDF]

Fish play a crucial role in the Bangladeshi diet, providing more than 60% of animal source food, representing a crucial source of micro-nutrients, and possessing an extremely strong cultural attachment.
Belton, B., Collis, W., Karim, M., Murshed-E-Jahan, K., Phillips, M., Thilsted, S.   +5 more
core  

An International, Prospective, Multicenter Evaluation of the Combination of AdvanDx Staphylococcus Quick FISH BC with mecA Xpress FISH for Detection of Methicillin-Resistant Staphylococcus aureus Isolates from Positive Blood Cultures [PDF]

, 2014
Hossein Salimnia, M. R. Fairfax, Paul Lephart, Margie Morgan, Jeremy J. Gilbreath, Susan M. Butler‐Wu, Kate Templeton, Fiona Hamilton, Feiyun Wu, Rebecca J. Buckner, D. Fuller, T. E. Davis, Ayman M. Abdelhamed, Michael R. Jacobs, Andy O. Miller, B. Pfrommer, Karen C. Carroll   +16 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Bioreproductive Variation in Populations of the Freshwater Mussel Anodonta cygnea (Linnaeus, 1771) Depending on the Aquatic Environment in which They Grow

Scientific Papers Animal Science and Biotechnologies
The freshwater clams Anodonta Cygnea are part of the aquatic population of the 3 studied fishponds. The witness pond (Wp) is similar in characteristics to their natural rearing environment, pond 1 (P2) is populated with uniform fish stock in terms of age,
Mariana Cristina Arcade, Mioara Costache, Daniela Radu, Marinela Gancea, Carmen Anca Anghelescu, Carmen Georgeta Nicolae   +5 more
doaj  

Integration of fish culture and poultry rearing in transplanted rice for nutritional security in smallholder farms. [PDF]

Sci Rep, 2020
Ramanathan K, Sangeeviraman V, Chandrahasan P, Chaudhary BN, Ramachandra SS.   +4 more
europepmc   +1 more source