Results 101 to 110 of about 793,847 (317)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Role of fish in enhancing ricefield ecology and in integrated pest management: summary report [PDF]

open access: yes
Summary report of the Third Asian Regional Rice-Fish Farming Research and Development Workshop, Indonesia, 1993. Includes sessions on ricefield ecology and fish; integrated pest management (IPM); research methodology; and IPM adoption.Rice-fish ...
dela Cruz, C.R. (ed.)
core  

Mariculture in California [PDF]

open access: yes, 1973
Mariculture in California is currently under development by several private concerns, universities, and by the California Department of Fish and Game.
Ebert, Earl E.
core  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Bioreproductive Variation in Populations of the Freshwater Mussel Anodonta cygnea (Linnaeus, 1771) Depending on the Aquatic Environment in which They Grow

open access: yesScientific Papers Animal Science and Biotechnologies
The freshwater clams Anodonta Cygnea are part of the aquatic population of the 3 studied fishponds. The witness pond (Wp) is similar in characteristics to their natural rearing environment, pond 1 (P2) is populated with uniform fish stock in terms of age,
Mariana Cristina Arcade   +5 more
doaj  

Integration of fish culture and poultry rearing in transplanted rice for nutritional security in smallholder farms. [PDF]

open access: yesSci Rep, 2020
Ramanathan K   +4 more
europepmc   +1 more source

Status and potential of aquaculture in small waterbodies (ponds and ditches) in Bangladesh [PDF]

open access: yes
A report on a survey on ponds and ditches in Bangladesh, done to determine their potential use for aquaculture.Aquaculture, Fish culture, Freshwater aquaculture, Pond Culture, Water bodies, Ponds, Bangladesh,
Ahmed, M.
core  

Integrating cultural, economic and environmental requirements for fish production in Borno State [PDF]

open access: yes, 2003
The study examines the integration of cultural, economic and environmental requirements for fish production in Borno State, Nigeria. A reconnaissance survey was conducted transferring some selected Local Government Areas.
Omoyeni, B.A., Raji, A.
core  

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