Results 71 to 80 of about 790,426 (315)

Assessment of metal contamination in the upper reaches of the Tichá Orlice River

Czech Journal of Animal Science, 2004
The aim of the present study was to assess metal contamination in the same reaches of the river, and thus to help explain unsatisfactory reproduction results in the reproduction of salmonoid fish. The contamination assessment was based on measuring metal
Z. Svobodová, O. Čelechovská, J. Kolářová, T. Randák, V. Žlábek   +4 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Ultrasonography Is a Valuable Tool for Assisting in Marine Fish Reproduction: Applications in Brazilian Sardine (Sardinella brasiliensis) and Lebranche Mullet (Mugil liza)

Fishes
Urogenital cannulation is a traditional method used in aquaculture to achieve sexual differentiation, but it is considered invasive. Ultrasonography is a valuable non-invasive tool for determining sex and gonadal development in fish species like mullet ...
Liseth Carolina Perenguez Riofrio, Sabrina Lara da Luz, Ingrith Mazuhy Santarosa, Maria Alcina de Castro, Everton Danilo dos Santos, Leticia Cordeiro Koppe de França, Karinne Hoffmann, Marco Shizuo Owatari, Aline Brum, Caio Magnotti   +9 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Growth and Oxidative Stress of Clownfish Amphiprion ocellaris Reared at Different Salinities

Fishes
Aquaculture of ornamental marine fish is often conducted in recirculating aquaculture systems (RAS) using artificial seawater. Considering the cost of salts to produce artificial seawater (salinity 35‰), we investigated the effect of different salinities
Mario Davi Dias Carneiro, Rafael Soriani de Medeiros, José Maria Monserrat, Ricardo Vieira Rodrigues, Luís André Sampaio   +4 more
doaj   +1 more source

Transfer of Green Fluorescent Protein (GFP) Gene to Betta splendens Embryos by Transfection and Electroporation Methods

Omni-Akuatika, 2018
Transfection and electroporation method shave a high possibility to apply towards transgenic production of small eggs size fish species.  This study aimed to examine the potential of transfection and electroporation methods to use for transferring a ...
Eni Kusrini, Alimuddin Alimuddin, Erma Primanita Hayuningtyas, Syuhada Restu Danupratama   +3 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Strategies for Prevention and Control of Vibriosis in Asian Fish Culture. [PDF]

Vaccines (Basel), 2022
Xu K, Wang Y, Yang W, Cai H, Zhang Y, Huang L.   +5 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The efficacy of various anaesthetics in tench (tinca tinca l.) related to water temperature

Veterinární Medicína, 2004
The effect of three different anaesthetics, 2-phenoxyethanol (0.6 ml/l), Propiscin (0.75 ml/l)and clove oil (0.033 ml/l), on adult tench (Tinca tinca L.) of mean body weight 260 g (66-583 g), of both sexes was tested at four different water temperatures (
J. Hamackova, A. Lepicova, P. Kozak, Z. Stupka, J. Kouril, P. Lepic   +5 more
doaj   +1 more source