Results 71 to 80 of about 793,847 (317)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Ultrasonography Is a Valuable Tool for Assisting in Marine Fish Reproduction: Applications in Brazilian Sardine (Sardinella brasiliensis) and Lebranche Mullet (Mugil liza)

Fishes
Urogenital cannulation is a traditional method used in aquaculture to achieve sexual differentiation, but it is considered invasive. Ultrasonography is a valuable non-invasive tool for determining sex and gonadal development in fish species like mullet ...
Liseth Carolina Perenguez Riofrio, Sabrina Lara da Luz, Ingrith Mazuhy Santarosa, Maria Alcina de Castro, Everton Danilo dos Santos, Leticia Cordeiro Koppe de França, Karinne Hoffmann, Marco Shizuo Owatari, Aline Brum, Caio Magnotti   +9 more
doaj   +1 more source

Review paper on the production trials of rice-cum fish culture - a transferable concept into Niger State, Nigeria [PDF]

, 1999
This paper reviews the production trials of rice-cum-fish culture. Rice and various fish species using rotation and concurrent methods of cultivation are used. The farming system is mostly practiced and researched in to in Southeast Asian countries.
Yaro, I.
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Growth and Oxidative Stress of Clownfish Amphiprion ocellaris Reared at Different Salinities

Fishes
Aquaculture of ornamental marine fish is often conducted in recirculating aquaculture systems (RAS) using artificial seawater. Considering the cost of salts to produce artificial seawater (salinity 35‰), we investigated the effect of different salinities
Mario Davi Dias Carneiro, Rafael Soriani de Medeiros, José Maria Monserrat, Ricardo Vieira Rodrigues, Luís André Sampaio   +4 more
doaj   +1 more source

Transfer of Green Fluorescent Protein (GFP) Gene to Betta splendens Embryos by Transfection and Electroporation Methods

Omni-Akuatika, 2018
Transfection and electroporation method shave a high possibility to apply towards transgenic production of small eggs size fish species.  This study aimed to examine the potential of transfection and electroporation methods to use for transferring a ...
Eni Kusrini, Alimuddin Alimuddin, Erma Primanita Hayuningtyas, Syuhada Restu Danupratama   +3 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Strategies for Prevention and Control of Vibriosis in Asian Fish Culture. [PDF]

Vaccines (Basel), 2022
Xu K, Wang Y, Yang W, Cai H, Zhang Y, Huang L.   +5 more
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The efficacy of various anaesthetics in tench (tinca tinca l.) related to water temperature

Veterinární Medicína, 2004
The effect of three different anaesthetics, 2-phenoxyethanol (0.6 ml/l), Propiscin (0.75 ml/l)and clove oil (0.033 ml/l), on adult tench (Tinca tinca L.) of mean body weight 260 g (66-583 g), of both sexes was tested at four different water temperatures (
J. Hamackova, A. Lepicova, P. Kozak, Z. Stupka, J. Kouril, P. Lepic   +5 more
doaj   +1 more source