Results 181 to 190 of about 2,800 (290)

ACLY‐Driven Metabolic Reprogramming Promotes Histone Acetylation and Inflammation‐Associated Fibrosis in Chronic Kidney Disease

open access: yesAdvanced Science, EarlyView.
This study reveals a citrate–ACLY–H3K27ac metabolic–epigenetic axis driving inflammatory gene activation and kidney fibrosis, highlighting ACLY inhibition as a potential therapeutic strategy for chronic kidney disease (CKD). ABSTRACT The mechanisms by which metabolic stress drives epigenetic dysregulation and fibrosis in chronic kidney disease (CKD ...
Chunxiu Du   +15 more
wiley   +1 more source

Noninvasive Focal Gene Delivery into the Cerebellum of Non‐Human Primates using Focused Ultrasound

open access: yesAdvanced Science, EarlyView.
Focal and non‐invasive viral vector delivery in non‐human primates remains a major challenge in translational neuroscience. Low‐intensity focused ultrasound was used to transiently open the blood–brain barrier and enable targeted gene delivery to the cerebellum.
Noelia Esteban‐García   +11 more
wiley   +1 more source

BIOECONOMIC ANALYSIS OF ALTERNATIVE SELECTION PATTERNS IN THE UNITED STATES ATLANTIC SILVER HAKE FISHERY

open access: yes
In this paper a bioeconomic simulation of the U.S. fisheries for silver hake, Merluccius bilinearis, is presented. The model design combines elements of age-structured population and harvest yield models with economics of the silver hake fishery.
Mayo, R.K.   +2 more
core  

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

open access: yesAdvanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang   +19 more
wiley   +1 more source

Electric‐Current‐Induced Phase Transformation in Cu6Sn5 Below Its Equilibrium Transition Temperature

open access: yesAdvanced Science, EarlyView.
Electric current induces a monoclinic‐to‐hexagonal phase transformation in Cu6Sn5 at a measured bulk temperature of ∼120°C, below the equilibrium transition temperature. Ex situ synchrotron x‐ray diffraction, TEM, and matched thermal controls show that current stressing promotes the formation of a retained hexagonal η‐phase post‐stress state not ...
Shih‐kang Lin   +3 more
wiley   +1 more source

Anticoagulant Effect and Platelet Bioactivities of a Novel Cephalopod Byproduct Oil. [PDF]

open access: yesMar Drugs
Tsamesidis I   +5 more
europepmc   +1 more source

Following the fishing trail: Detecting fishing discards in seabirds through DNA metabarcoding

open access: yes
Upwelling regions along the northwest coast of Africa are known for their high productivity, which attracts both marine predators and intensive fishing activities. Understanding the impact of fishery discards on seabird populations is essential for effective conservation, as changes in fisheries management could significantly affect food availability ...
openaire   +1 more source

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