Results 201 to 210 of about 1,659 (252)

Mapping Embryonic Mouse Lung Development Using Enhanced Spatial Transcriptomics

Advanced Science, EarlyView.
The mammalian lung contains ∼50 cell types arranged along the airway epithelium. Here, deterministic barcoding sequencing (DBiT‐seq) is optimized to nearly double transcript recovery, enabling highly sensitive spatial mapping of the embryonic mouse lung.
Pengfei Zhang, Benjamin K. Law, Niles Huang, Katharine Goodwin, Celeste M. Nelson, Michelle M. Chan   +5 more
wiley   +1 more source

Mamba-YOLO-SRC: An Automatic Deep Learning Framework for Respiratory Behavior Detection in the Chinese Giant Salamander. [PDF]

Animals (Basel)
Mao D, Zhou Y, Shi C, Zhang X, Chen G, Chen Y, Luo Q.   +6 more
europepmc   +1 more source

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

From Molecular Visualization to Spatial Landscapes: Engineering the Next Generation of In Situ Hybridization. [PDF]

Genes (Basel)
Li Z, Luo M, Zhu M, Bai Y.
europepmc   +1 more source

SIRT5‐Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate‐Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis

Advanced Science, EarlyView.
The SIRT5/ACAA2 axis maintains lipid metabolic homeostasis in RTECs by promoting ACAA2 desuccinylation and preserving its stability and enzymatic activity, thereby sustaining FAO and limiting PUFA and PUFA‐containing phospholipid accumulation. Under CaOx stress, SIRT5 downregulation impairs FAO, promotes oxidative stress and ferroptosis, and enhances ...
Qinhong Jiang, Caitao Dong, Yuchen Liu, Yuanquan Lou, Wenlong Lin, Sheng Li, Ziqi He   +6 more
wiley   +1 more source

Marine-derived PUFAs and peptides for aging-related memory deficits: processing methods, pharmacokinetics, mechanistic insights, and clinical application. [PDF]

Front Nutr
Yang Z, Deng W, Lu Q, Zhou Z, Song C, Naqvi SN.   +5 more
europepmc   +1 more source

Macrophage Dab1 Links Early Hypoxia to Adaptive Angiogenesis to Drive Peripheral Nerve Repair

Advanced Science, EarlyView.
Schematic diagram illustrating the Dab1‐linked hypoxia signaling pathway that accelerates angiogenesis and consequent nerve regeneration. Following PNI, a hypoxic microenvironment develops. Hypoxia induces macrophage Dab1 phosphorylation, resulting in NHE‐1 upregulation, HIF‐1α stabilization, and VEGF‐A expression. This cascade promotes angiogenesis in
Xiongyao Zhou, Fan Zhang, Jiangbo Wang, Huiyuan Wang, Zongqiang Wang, Qianqian Wang, Chuikai Meng, Jialu Sun, Han Wang, Weiye Li, Ziyi Zhao, Le Qi, Xiaosong Gu, Shusen Cui, Rangjuan Cao   +14 more
wiley   +1 more source

Do Boat Traffic and Habitat Features Shape Habitat Use by Guiana Dolphins (<i>Sotalia guianensis</i>) in a Brazilian Estuary? [PDF]

Ecol Evol
Lima A, Giné GAF, Cruz KTS, Teixeira NN, Strenzel GMR, Le Pendu Y.   +5 more
europepmc   +1 more source

Multivariate Gas Sensor E-Nose System with PARAFAC and Machine Learning Modeling for Quantifying and Classifying the Impact of Fishing Gears. [PDF]

Sensors (Basel)
Silva-Alvarado VL, Lloret J.
europepmc   +1 more source

Sustainability-oriented recovery of antioxidant and ACE-inhibitory low-molecular-weight peptide fractions from <i>Thunnus albacares</i> by-products via enzymatic hydrolysis and membrane ultrafiltration. [PDF]

Front Nutr
Finicelli M, De Luca I, Conte R, Galderisi U, Melone MAB, Peluso G, Di Salle A.   +6 more
europepmc   +1 more source