Results 211 to 220 of about 509,696 (307)

Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss

open access: yesAdvanced Science, EarlyView.
 . ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao   +9 more
wiley   +1 more source

Cis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa

open access: yesAdvanced Science, EarlyView.
A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui   +9 more
wiley   +1 more source

Oil‐Coated Nanoplastics Induce Rapid Membrane Disruption and Severe Intestinal Injury

open access: yesAdvanced Science, EarlyView.
Oil‐rich food contact dramatically amplifies MNP release from plastic takeout containers, producing oil‐coated nanoplastics with altered surface properties and rapid membrane‐disruptive effects. These particles cause severe intestinal barrier damage and immune dysfunction in mice, and risk modeling suggests that long‐term gastrointestinal burdens may ...
Ruwen Xie   +17 more
wiley   +1 more source

Defatted Black Soldier Fly Meal as a Dietary Protein Source for Grey Mullet (<i>Mugil cephalus</i>): Effects on Growth Performance, Gut Morphology, Spleen and Liver Health. [PDF]

open access: yesAnimals (Basel)
Randazzo B   +12 more
europepmc   +1 more source

The first direct evidence of a Late Devonian coelacanth fish feeding on conodont animals. [PDF]

open access: yesNaturwissenschaften, 2017
Zatoń M   +4 more
europepmc   +1 more source

Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro

open access: yesAdvanced Science, EarlyView.
The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel   +15 more
wiley   +1 more source

Effect of stocking density on growth performance, gross energy, proximate analysis of meat, and stress response of mahseer (<i>Tor soro</i>) fry. [PDF]

open access: yesPeerJ
Prihadi TH   +18 more
europepmc   +1 more source

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