Results 51 to 60 of about 42,402 (318)

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

Redox‐Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis

Advanced Science, EarlyView.
In dormant seeds (low ROS), GBF1 forms liquid condensates to repress the germination gene CathB3, and the chaperone GIP1 maintains condensate liquidity and repressive activity. Upon imbibition (high ROS), ROS oxidize GIP1 during germination, impairing its chaperone function.
Yunying Wang, Xiaofeng Fang
wiley   +1 more source

Predicting food consumption and production in fish populations : allometric scaling and size-structured models

, 2010
Life-history traits in fish populations are highly correlated. A subset of these correlations are called allometric scaling, they refer to biological processes which can be described using body size as independent variable.
Wiff, Rodrigo
core   +1 more source

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

Productive indices of age-2 carp after application of a prebiotic in their feeding

Ribogospodarsʹka Nauka Ukraïni, 2019
Purpose. To investigate the efficiency of the supplementation of the basic diet of age-3 carp with the prebiotic "Actigen" in pond conditions. To provide control over the aquatic environment conditions, to determine the effect of the tested supplement on
O. Dobryanska, O. Deren, M. Korylyak, T. Hryhorenko   +3 more
doaj   +1 more source

Atomic Tuning of Metal‐Support Interactions for Pathway‐Selective CO2 Photoreduction on TiO2

Advanced Science, EarlyView.
Single‐atom Fe and Cu catalysts anchored on TiO2 steer photocatalytic CO2 reduction toward distinct pathways. Fe sites favor rapid *CO desorption and selective CO formation, whereas Cu sites stabilize *CHO intermediates, enabling deep reduction and C─C coupling. Combined spectroscopy and DFT calculations reveal how metal–support interactions and oxygen
Dongyun Kim, Wonjae Ko, Byoung‐Hoon Lee, Sanghoon Kim, Yun Do Kim, Hyunsoo Ahn, Yoon Jung, Chan Woo Lee, Kug‐Seung Lee, Eunhee Gong, Junho Lee, Minho Kim, Taeghwan Hyeon, Su‐Il In   +13 more
wiley   +1 more source

THE CONCEPTION OF FISHERIES DEVELOPMENT IN DNIPROPETROVS’K REGION FOR THE NEXT FIVE YEARS

Ribogospodarsʹka Nauka Ukraïni, 2015
Purpose. To analyse the current state of fisheries in Dnipropetrovs’k region and elaborate a strategy of their development for the period of 2015–2019. Methodology.
O. Fedonenko, N. Esipova, O. Marenkov, T. Sharamok   +3 more
doaj   +1 more source

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

Utilization of wetland ecosystem through fish-crop diversification for enhanced productivity and economic stability for fish-farm community of Indian sub-continent [PDF]

This paper deals with a number of case studies that were undertaken during the last 8- 10 years in utilizing divergent æTalÆ wetland ecosystems (deep, semi-deep, temporary in a range of agro-ecological zones like NAZ, OAZ and Coastal Zone of the region)
Dasgupta, M., Jana, K., Maiti, A.K., Basu, D., Puste, A.M., Roy, A., Pramanick, B.P.R.   +6 more
core  

Fish assemblages associated with natural and anthropogenically-modified habitats in a marine embayment: Comparison of baited videos and opera-house traps

, 2013
Marine embayments and estuaries play an important role in the ecology and life history of many fish species. Cockburn Sound is one of a relative paucity of marine embayments on the west coast of Australia.
Timothy J Langlois, Fairclough, D., Coutts, T., Langlois, T.J., Coutts, Teresa B, Fairclough, David V, Langlois, Timothy J, Coutts, T.B., Langlois, T., David V Fairclough, Lewis, Paul, Wakefield, Corey B, Corey B Wakefield, Fairclough, D.V., Paul D Lewis, Lewis, P.D., Wakefield, C.B., Lewis, P., Teresa B Coutts, Wakefield, Corey   +19 more
core   +2 more sources