Results 61 to 70 of about 454,690 (308)

An overview of the utilisation of microalgae biomass derived from nutrient recycling of wet market wastewater and slaughterhouse wastewater

International Aquatic Research, 2017
Microalgae have high nutritional values for aquatic organisms compared to fish meal, because microalgae cells are rich in proteins, lipids, and carbohydrates. However, the high cost for the commercial production of microalgae biomass using fresh water or
A. Y. Maizatul, Radin Maya Saphira Radin Mohamed, Adel A. Al-Gheethi, M. K. Amir Hashim   +3 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition [PDF]

, 2015
Although the prevalence of malnutrition in the old age is increasing worldwide a synthetic understanding of the impact of aging on the intake, digestion, and absorption of nutrients is still lacking.
Bordoni, Alessandra, Dupont, Didier, Gille, Doreen, Kachal, Josefa, Peyron, Marie-Agnès, Pinto, Paula, Rémond, Didier., Santos, Claudia Nunes Dos, Shahar, Danit R., Tomás-Cobos, Lidia, Vergères, Guy, Walther, Barbara   +11 more
core   +4 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

New Insight into Utilization of Fish By-Product Proteins and Their Skin Health Promoting Effects

Marine Drugs
In regions reliant on fisheries for livelihoods, a significant number of fish by-products are generated annually due to processing. These discarded parts contain valuable biological resources, such as proteins, fish oils, and trace elements, thus holding
Dongcheng Liu, Yongxin Ren, Saiyi Zhong, Baojun Xu   +3 more
doaj   +1 more source

Application of Outer Membrane Protein-Based Vaccines Against Major Bacterial Fish Pathogens in India

Frontiers in Immunology, 2020
Aquaculture is one of the fastest-growing food-producing sectors in the world. However, its growth is hampered by various disease problems due to infectious microorganisms, including Gram-negative bacteria in finfish aquaculture.
Biswajit Maiti, Saurabh Dubey, Hetron Mweemba Munang'andu, Iddya Karunasagar, Indrani Karunasagar, Indrani Karunasagar, Øystein Evensen   +6 more
doaj   +1 more source

Identification of a low digestibility δ-Conglutin in yellow lupin (Lupinus luteus L.) seed meal for atlantic salmon (Salmo salar L.) by coupling 2D-PAGE and mass spectrometry. [PDF]

PLoS ONE, 2013
The need of quality protein in the aquaculture sector has forced the incorporation of alternative plant proteins into feeding diets. However, most plant proteins show lower digestibility levels than fish meal proteins, especially in carnivorous fishes ...
Takahiro Ogura, Adrián Hernández, Tomoko Aizawa, Jun Ogihara, Michio Sunairi, Javier Alcaino, Haroldo Salvo-Garrido, Iván J Maureira-Butler   +7 more
doaj   +1 more source

A haplotype-resolved draft genome of the European sardine (Sardina pilchardus) [PDF]

, 2019
The European sardine (Sardina pilchardus Walbaum, 1792) is culturally and economically important throughout its distribution. Monitoring studies of sardine populations report an alarming decrease in stocks due to overfishing and environmental change ...
Canario, A.V.M., Cox, Cymon, De Moro, Gianluca, Garcia, Carlos, Louro, Bruno, Sabatino, Stephen J., Santos, António M., Veríssimo, Ana   +7 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source