Results 71 to 80 of about 225,374 (309)
Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang +12 morewiley +1 more sourceDistinctive expansion of potential virulence genes in the genome of the oomycete fish pathogen Saprolegnia parasitica [PDF]
, 2013 Peer ...Marco Mammella (421707), Julio C. Vega-Arreguin (421715), Horner, N. R., van Rooyen, D., Young, S. K., Guido van den Ackerveken (5650309), Stassen, J.H.M., Javier Dieguez-Uribeondo, Berg, H., Brett M. Tyler (19744), James Christie, Young, Sarah K, Grenville-Briggs, Laura J.,, Grenville-Briggs, L., Arnaud Bottin (41550), Elzbieta Rzeszutek (421711), Andrew J. Phillips (334915), Rooyen, D., van, van den Berg, H., Stan Oome (421709), Chad Nusbaum (253636), van den Berg, Herbert, Sarah K Young, Pieter van West (205267), Christie, James, Berend Snel, Rzeszutek, Elzbieta,, Lars Löbach, Horner, N.R., Díaz-Moreno, S.M., Sarah K. Young (178826), Morris, P., Seidl, M.F., de Bruijn, I., Joshua Z. Levin (177182), Levin, Joshua Z, Sucheta Tripathy, Meijer, Harold J. G., Grenville-Briggs, L. J., Secombes, Chris J, Secombes, Chris J., Grenville-Briggs, Laura J, Carsten Russ, Oome, Stan, Wawra, Stephan, Snel, Berend, Belmonte, Rodrigo, Mammella, M., Marcia Saraiva (421712), Elodie Gaulin (40047), Rodrigo Belmonte, Dieguez-Uribeondo, J., Marco Mammella, Sara M. Díaz-Moreno (421704), Qiandong Zeng (178764), Grenville-Briggs, L.J., Lin Fan (281949), Chad Nusbaum, Dumas, B., Levin, J.Z., Andrew J Phillips, Julio C Vega-Arreguin, Horner, Neil R, Sub Theoretical Biology & Bioinformatics, Haas, B., Dep Biologie, Tyler, Brett M., Meijer, H.J., van den Ackerveken, G., Löbach, Lars, Vega-Arreguin, Julio C, Russ, C., David van Rooyen, et al., Vega-Arreguin, Julio C., Bruijn, I., de, Govers, F., van West, Pieter, van den Ackerveken, A.F.J.M., Díaz-Moreno, S., Nusbaum, Chad, Chris J Secombes, Vega-Arreguin, J. C., Sub Plant-Microbe Interactions, Gaulin, Elodie, Sykes, Sean, Meijer, H.J.G., Irene de Bruijn, Seidl, Michael F., Wawra, S., Stassen, Joost H. M., Nusbaum, C., Paul Morris, Secombes, C.J., Stassen, Joost H M, Stephan Wawra, Laura J. Grenville-Briggs (421705), Bernard Dumas, Saraiva, M., Jiang, R., Phillips, Andrew J, Belmonte, R., Grenville-Briggs, Laura J., de Bruijn, Irene, Stan Oome, Haas, B. J., Harold J. G. Meijer (227595), Saraiva, Marcia, Qiandong Zeng, Rzeszutek, E., Stassen, J. H., Young, Sarah K., Young, S.K., Neil R Horner, Phillips, A. J., Joshua Z Levin, Jiang, R. H., Theoretical Biology and Bioinformatics, Stephan Wawra (421716), Joost H. M. Stassen (221771), David van Rooyen (421710), Bulone, Vincent, Irene de Bruijn (43879), van West, P., Sucheta Tripathy (19740), Secombes, C. J., Michael F. Seidl (221772), Snel, B., Levin, Joshua Z., Michael F Seidl, Gaulin, E., Bottin, A., Joost H M Stassen, Löbach, L., West, P., van, Bernard Dumas (40050), Díaz-Moreno, Sara M., Loebach, Lars, Guido van den Ackerveken, Lars Löbach (421702), Lin Fan, Haas, Brian J, Bulone, Vincent,, Herbert van den Berg, Jiang, Rays H. Y., Sean Sykes (158441), Vincent Bulone, Seidl, Michael F, Tripathy, S., Elzbieta Rzeszutek, Rzeszutek, Elzbieta, van Rooyen, David, Tyler, Brett M, Zeng, Qiandong, Levin, J. Z., Dieguez-Uribeondo, Javier, Morris, Paul, Díaz-Moreno, S. M., Govers, Francine, Tyler, B.M., Vincent Bulone (243055), Jiang, R.H.Y., Meijer, Harold J G, Marcia Saraiva, Neil R. Horner (421706), Arnaud Bottin, Meijer, H. J., Jiang, Rays H Y, Fan, Lin, Young, Sarah, Brett M Tyler, Bulone, V., Laura J Grenville-Briggs, Jiang, R.H.I., Elodie Gaulin, Horner, N., James Christie (421703), Tyler, B. M., Christie, J., Sean Sykes, de Haas, B.J., Sara M Díaz-Moreno, Francine Govers (52155), Francine Govers, Paul Morris (421708), van den Ackerveken, Guido, West, P., Oome, S., Berend Snel (5539), Zeng, Q., Haas, B.J., Chris J. Secombes (421713), Diaz-Moreno, Sara M.,, Vega-Arreguin, J.C., Javier Dieguez-Uribeondo (421717), Haas, Brian J., Fan, L., Carsten Russ (263594), Herbert van den Berg (421714), Sykes, S., Meijer, H., Stassen, J.H., Bottin, Arnaud, Horner, Neil R., Rays H Y Jiang, Ackerveken, G., van den, Russ, Carsten, Pieter van West, Levin, J., Rooyen, D., Plant Microbe Interactions, Harold J G Meijer, Rodrigo Belmonte (421701), Mammella, Marco, Phillips, Andrew J., Phillips, A.J., Brian J. Haas (81121), Rays H. Y. Jiang (421700), Seidl, M. F., Dumas, Bernard, Tripathy, Sucheta, Díaz-Moreno, Sara M, Brian J Haas +222 morecore +1 more sourceIMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd +9 morewiley +1 more sourceKeratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer +13 morewiley +1 more sourceDigestion and metabolism of carbohydrates in fish [PDF]
, 2014 This thesis deals with the digestion and metabolism of carbohydrates in Arctic charr, Eurasian perch and tilapia. Two sources of carbohydrates, native starch (wheat) and chitin (zygomycete biomass), were evaluated.Abro, Ranicore Short and long peptidoglycan recognition proteins (PGRPs) in zebrafish, with findings of multiple PGRP homologs in teleost fish [PDF]
, 2007 Peptidoglycan recognition protein (PGRP) specifically binds to peptidoglycan and is considered to be one of the pattern recognition proteins in the innate immunity of insect and mammals. Using a database mining approach and RT-PCR, multiple peptidoglycan Wei, L. L., Chang, M. X., Nie, P., Nie, P, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China +3 morecore +1 more sourceEstablishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns +10 morewiley +1 more source
