Results 61 to 70 of about 2,044,793 (270)

Fisher information and asymptotic normality in system identification for quantum Markov chains

, 2011
This paper deals with the problem of estimating the coupling constant $\theta$ of a mixing quantum Markov chain. For a repeated measurement on the chain's output we show that the outcomes' time average has an asymptotically normal (Gaussian) distribution,
A. S. Holevo, A. van der Vaart, C. W. Helstrom, E. Davies, E. L. Lehmann, L. Le Cam, M. Guţă, M. Hayashi, M. Hayashi, Mădălin Guţă, S. Meyn   +10 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Escort--Husimi distributions, Fisher information and nonextensivity

, 2004
We evaluate generalized information measures constructed with Husimi distributions and connect them with the Wehrl entropy, on the one hand, and with thermal uncertainty relations, on the other one. The concept of escort distribution plays a central role
A. Plastino, Abe, Abe, Anderson, Anderson, Beck, Bradley, Casas, Cramer, Davis, F. Pennini, Frieden, Frieden, Husimi, Katz, Klauder, Latora, Lieb, Martı́nez, Martı́nez, Pennini, Pennini, Plastino, Plastino, Plastino, Schnack, Tsallis, Tsallis, Tsallis, Tsallis, Wehrl   +30 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Warped Riemannian metrics for location-scale models

, 2017
The present paper shows that warped Riemannian metrics, a class of Riemannian metrics which play a prominent role in Riemannian geometry, are also of fundamental importance in information geometry.
A Terras, AW Knapp, B O’Neill, B Unal, C Atkinson, D Wierstra, DG Luenbeger, E Liao, EH Spanier, EL Lehmann, EP Hsu, F Dobarro, G Cheng, G Gallavotti, GA Young, GJ McLachlan, GN Watson, I Chavel, J Bensadon, JE Marsden, JM Lee, KV Mardia, M Arnaudon, M Arnaudon, M Emery, MP Do Carmo, N Ay, N Ikeda, NN Chentsov, O Kallenberg, P Petersen, PA Absil, PE Kloeden, R. L. Bishop, S Amari, S Helgason, S Lang, S Said, S Said, SI Amari, X Pennec, Y Chikuse, Y Ollivier   +42 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Fisher Information Analysis of earthquake-related geoelectrical signals [PDF]

Natural Hazards and Earth System Sciences, 2005
We studied the time fluctuations in the dynamics of geoelectrical data, recorded in Tito site, which is located in a seismic area of southern Italy. We used the Fisher Information Measure, which is a powerful tool to investigate complex and nonstationary
L. Telesca, V. Lapenna, M. Lovallo
doaj  

Fidelity and Fisher information on quantum channels

New Journal of Physics, 2017
The fidelity function for quantum states has been widely used in quantum information science and frequently arises in the quantification of optimal performances for the estimation and distinguishing of quantum states.
Haidong Yuan, Chi-Hang Fred Fung
doaj   +1 more source