Results 81 to 90 of about 770,655 (252)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Fisher Information Flow in Artificial Neural Networks

Physical Review X
The estimation of continuous parameters from measured data plays a central role in many fields of physics. A key tool in understanding and improving such estimation processes is the concept of Fisher information, which quantifies how information about ...
Maximilian Weimar, Lukas M. Rachbauer, Ilya Starshynov, Daniele Faccio, Linara Adilova, Dorian Bouchet, Stefan Rotter   +6 more
doaj   +1 more source

Generalized Wavelet Fisher’s Information of 1/fα Signals

Advances in Mathematical Physics, 2015
This paper defines the generalized wavelet Fisher information of parameter q. This information measure is obtained by generalizing the time-domain definition of Fisher’s information of Furuichi to the wavelet domain and allows to quantify smoothness and ...
Julio Ramírez-Pacheco, Homero Toral-Cruz, Luis Rizo-Domínguez, Joaquin Cortez-Gonzalez   +3 more
doaj   +1 more source

Fisher Information and the Combination of RGB Channels [PDF]

, 2013
We introduce a method to combine the color channels of an image to a scalar valued image. Linear combinations of the RGB channels are constructed using the Fisher-Trace-Information (FTI), defined as the trace of the Fisher information matrix of the Weibull distribution, as a cost function.
Reiner Lenz, Vasileios Zografos
openaire   +2 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Combining estimators of a common parameter across samples

Statistical Theory and Related Fields, 2018
In many settings, multiple data collections and analyses on the same topic are summarised separately through statistical estimators of parameters and variances, and yet there are scientific reasons for sharing some statistical parameters across these ...
Eric Slud, Ilia Vonta, Abram Kagan
doaj   +1 more source

Fisher Information and Spline Interpolation

The Annals of Statistics, 1974
It is shown that among all cumulative distribution functions passing through $k \geqq 2$ given points there is a unique one with minimal Fisher information; it is obtained by a curious type of spline interpolation. This answers some questions raisd by D. G. Kendall and J. W. Tukey.
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Assessing spatiotemporal change in coral reef social-ecological systems

Ecology and Society
Coral reef resilience is eroding at multiple spatial scales globally, with broad implications for coastal communities, and is thus a critical challenge for managing marine social-ecological systems (SESs).
Tarsha Eason, Ahjond Garmestani
doaj   +1 more source