Results 91 to 100 of about 16,637,647 (281)

Combining estimators of a common parameter across samples

open access: yesStatistical Theory and Related Fields, 2018
In many settings, multiple data collections and analyses on the same topic are summarised separately through statistical estimators of parameters and variances, and yet there are scientific reasons for sharing some statistical parameters across these ...
Eric Slud, Ilia Vonta, Abram Kagan
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Prior-based Bayesian information criterion

open access: yesStatistical Theory and Related Fields, 2019
We present a new approach to model selection and Bayes factor determination, based on Laplace expansions (as in BIC), which we call Prior-based Bayes Information Criterion (PBIC).
M. J. Bayarri   +5 more
doaj   +1 more source

The Roy B. Fisher, D.O. Collection

open access: yes, 1998
Finding aid for the Roy B. Fisher, D.O. CollectionRoy Benjamin Fisher, D.O. (1910-1998), was a prominent physician in Fort Worth, Texas and one of founders of the Fort Worth Osteopathic Hospital (later the Osteopathic Medical Center of Texas).
Fisher, Roy B.
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Assessing spatiotemporal change in coral reef social-ecological systems

open access: yesEcology and Society
Coral reef resilience is eroding at multiple spatial scales globally, with broad implications for coastal communities, and is thus a critical challenge for managing marine social-ecological systems (SESs).
Tarsha Eason, Ahjond Garmestani
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Physical symmetries and Fisher's information measure

open access: yesPhysics Letters A, 2009
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Pennini, F.   +3 more
openaire   +5 more sources

Optimal Experimental Design for Fuel Cell Model Parameter Identification

open access: yesIEEE Access
Model-based development provides a systematic approach for investigating fuel cell (FC) and fuel cell system (FCS) operation. It places particular emphasis on understanding reaction kinetics, transport phenomena, and aging mechanisms as functions of ...
Luis M. Winkler   +2 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

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