Results 101 to 110 of about 16,637,647 (281)

Fisher & Beyond

open access: yes, 2013
In lieu of an abstract, below is the essay\u27s first paragraph. I began my journey at St. John Fisher College in the fall of 2003; the education I received from Fisher was invaluable.
Hall, Shawn
core   +1 more source

Information-Geometric Models in Data Analysis and Physics II

open access: yesMathematics
This paper continues the development of information-geometric models for data analysis and physics by focusing on their formulation and interpretation through variational principles.
D. Bernal-Casas, José M. Oller
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Structures in Sound: Analysis of Classical Music Using the Information Length

open access: yesEntropy, 2016
We show that music is represented by fluctuations away from the minimum path through statistical space. Our key idea is to envision music as the evolution of a non-equilibrium system and to construct probability distribution functions (PDFs) from musical
Schuyler Nicholson, Eun-jin Kim
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Fourth And Fifth Order Efficiency: Fisher Information

open access: yes
Loss of (Fisher) information, whose concept was defined by Fisher, is one of important measures of asymptotic efficiency. Based on Fisher information, this paper studies fourth and fifth order asymptotic efficiency of estimators in a curved exponential ...
Yutaka Kano, Fisher Information
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Copy of John Fisher's diary, made by him, 1776-1777

open access: yes
Typescript copy of diary entries made by John Fisher (1755-1843), the great-grandfather of George Brayton Fisher, for a period covering 14 July 1776 to 10 August 1777.
Fisher, John, 1755-1843;
core  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Fisher Information and Spline Interpolation

open access: yesThe Annals of Statistics, 1974
It is shown that among all cumulative distribution functions passing through $k \geqq 2$ given points there is a unique one with minimal Fisher information; it is obtained by a curious type of spline interpolation. This answers some questions raisd by D. G. Kendall and J. W. Tukey.
openaire   +2 more sources

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